Results 41 to 50 of about 502,400 (402)

Las normas y su puesta en vigor: respuesta a Josep Corbí

open access: yesCrítica, 2018
En su discusión “Obras de ficción, formas de conciencia y literatura”, Josep Corbí formula una serie de críticas certeras a mis ideas sobre la distinción que he hecho entre ficción y no ficción en Relatar lo ocurrido como invención (2016).
Manuel García-Carpintero
doaj   +1 more source

O ensino de Língua Portuguesa no contexto da cultura digital

open access: yesRevista Ibero-Americana de Estudos em Educação, 2023
Este artigo analisa as práticas educativas utilizadas por professoras de Língua Portuguesa, mais especificamente relacionadas sobre as práticas de multiletramentos, abrangendo a cultura digital nos processos educativos.
Eduardo Fofonca   +2 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

An Assessment of the Visual Appropriateness of Selected Brand Logos

open access: yesExchanges, 2021
This paper focuses on assessing the appropriateness of selected logos of popular brands. The paper enunciates the relevance of logos to the public perception of brands. Logos function as signifiers, denotative, point of contact and identifiers.
Afeez Siyanbola   +1 more
doaj   +1 more source

Consumer preferences and willingness-to-pay for organic certification logos: Recommendations for actors in the organic sector. Report of the CERTCOST project [PDF]

open access: yes, 2011
In many European countries, a variety of different organic certification logos and schemes is found in the market. In the countries of the European Union (EU), the new mandatory EU logo for organic food was introduced in July 2010, so that other organic ...
Hamm, Ulrich, Janssen, Meike
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

INTELLIGIBILITY IN CONTEXT SCALE AS A TOOL FOR A QUICK AND RELIABLE ASSESSMENT OF CHILDREN‘S SPEECH EFFICIENCY

open access: yesSlovenska pediatrija, 2023
In preschoolers, we can observe speech discrepancies very frequently. Atypical discrepancies are important in children’s speech intelligibility and, consequently, their communication self-esteem.
Martina Ozbič
doaj   +1 more source

Transcendent Temporality

open access: yesTheoLogica, 2021
This paper looks at several key motivations behind the prisoner of time objection and a view against which it is leveled, the Oxford School of divine temporality, with respect to the Christian God.
D. T. Everhart
doaj   +1 more source

Motor racing, tobacco company sponsorship, barcodes and alibi marketing [PDF]

open access: yes, 2011
Background Sponsorship of Formula One (F1) motor racing, which has been used as an indirect medium of tobacco advertising for several decades, was prohibited by the 2005 European Union Tobacco Advertising Directive.
Britton, John, Grant-Braham, Bruce
core   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

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