Results 51 to 60 of about 80,112 (295)

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

ECONOMIC IMPACTS OF AN EARTHQUAKE DISASTER AND COVID-19 IN ALBANIA [PDF]

Buletin ştiinţific: Universitatea din Piteşti. Seria Ştiinţe Economice, 2020
The earthquake, occurred on 26th November 2019, caused considerable material and financial damages. According to a document compiled by the Albanian Government with the support of several International Institutions, the earthquake affected directly and ...
Blerina BANUSHI, Iva SULAJ
doaj  

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Consumer Willingness-To-Pay for Different Organic Certification Logos in Turkey [PDF]

, 2012
Using data from focus group discussions with consumers and a choice experimentconducted in some of Turkey’s major cities, this study investigates whetherTurkish consumers prefer certain organic labelling schemes over others attemptsand to elicit their ...
Boyaci, M., Janssen, M., Hamm, U., Abay, C., Karahan Uysal, Ö, Miran, B.   +5 more
core   +1 more source

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System

Advanced Science, EarlyView.
Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.
Branislava Rankovic, Zachary M. Geisterfer, Akshita Chhabra, Vladimir M. Jovanovic, Ian Seim, Christian Hoffmann, Antonela Condric, Gerard Aguilar Pérez, Rinse de Boer, Lars T. Hofstede, Jingao Sun, Kiara Freitag, Katja Nowick, Marina Jendrach, Frank L. Heppner, Vladimir Despic, Michaela Müller‐McNicoll, Stephan Sigrist, Geert van den Bogaart, Sofiia Reshetniak, Amy S. Gladfelter, Dragomir Milovanovic   +21 more
wiley   +1 more source

¿Existen diferencias esenciales entre representaciones artísticas y científicas? Consecuencias para una teoría general de la representación científica

Análisis Filosófico, 2014
En este trabajo, partiendo de un experimento mental y de una exégesis del concepto de representación artística en la obra de Arthur Danto, mostraremos que hay serias dificultades para trazar una distinción de carácter esencialista entre representaciones ...
Romina Zuppone
doaj   +1 more source

The LOGOS experience

Logos, 1994
Logos founder and editor emeritus Gordon Graham reflects on his nearly two-decade love affair with this journal which he launched in 1990. After a long and distinguished career in publishing—including from 1974 to 1990 as chairman and chief executive of Butterworths, the legal and scientific publisher that has been a division of Reed International ...
openaire   +2 more sources

A Site‐Aware Representation Learning Framework For Unified Molecular Interaction Modeling and Generative Design

Advanced Science, EarlyView.
MolDBG is a site‐aware, sequence‐only framework that unifies drug‐target affinity prediction, binding‐site identification, and affinity‐conditioned molecular generation for structured proteins. Guided by multi‐task binding‐site supervision, it aligns interaction‐critical residues before learning drug‐target representations and simultaneously infers ...
Gang Luo, Qianqian Zhang, Chenhao Wang, Zhiheng Yi, Alex Jinpeng Wang, Jing Tang, Min Li   +6 more
wiley   +1 more source

Stabilizing Zinc Anodes via a Zeolite‐Induced Localized Supersaturated Electrolyte Interface

Angewandte Chemie, EarlyView.
A low‐Si/Al‐ratio ZSM‐5 (LZ5) interphase induces a localized supersaturated electrolyte interface on Zn, with a local Zn2+ concentration exceeding 10 M in a 1 M ZnSO4 bulk electrolyte. Continuous Zn2+ enrichment within the zeolite nanochannels creates an H2O‐deficient, anion‐enriched solvation environment, promoting rapid desolvation, uniform ...
Xiaoqi Liu, Yipu Xu, Linjiao Wei, Hongman Sun, Zhengxing Qin, Xizhi Zhang, Dahai Zhang, Xianguo Li, Han Hu, Wei Xing, Yu Zhang, Bin Luo, Zifeng Yan   +12 more
wiley   +2 more sources