Results 41 to 50 of about 173,494 (288)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Loneliness predicts worse Parkinsonism: a longitudinal, community-based, clinical-pathological study
npj Parkinson's DiseaseLoneliness is increasingly acknowledged as important in parkinsonism-related disorders. However, little is known about reciprocal longitudinal relationships between loneliness and parkinsonism. In this study, 3,099 community-based individuals (Mage=78.09,
David Andrés González +3 more
doaj +1 more source
All the lonely people: loneliness in Australia, 2001-2009 [PDF]
, 2012 Finding that the incidence of loneliness in Australia is growing, this paper studies the long-term pattern of loneliness and identifies demographic characteristics and risk indicators associated with this experience. The use of online social networking
David Baker
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
European PsychiatryIntroduction While transient loneliness refers to feelings that last for a short time (less than two years), chronic loneliness alludes to feelings that last more than two years.
J. Domènech-Abella, C. Domènech
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
JMIR Formative Research, 2021 BackgroundLoneliness is a public health concern, and increasingly, individuals experiencing loneliness are seeking support on online forums, some of which focus on discussions around loneliness (loneliness forums).
Anietie Andy
doaj +1 more source
“Low‐Positive” MOG‐IgG Cases Among Adults With a First Event Suggestive of Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To determine the prevalence and clinical characteristics of patients with “low‐positive” (LP) MOG‐IgG (titres 1:160–1:320) among adults with a first demyelinating event (FDE) suggestive of multiple sclerosis (MS). Methods From the Barcelona CIS inception cohort, we included adult patients with serum collected ≤ 6 months from the FDE.
Javier Villacieros‐Álvarez +29 more
wiley +1 more source
Causes of involuntary loneliness among adolescents and young adults: an integrative review
International Journal of Adolescence and Youth, 2022 Loneliness among adolescents and young adults is a multifaceted phenomenon. The aim of the study was to synthesize the existing knowledge on the different causes of involuntary loneliness among adolescents and young adults.
Yulia Korzhina +3 more
doaj +1 more source