Results 101 to 110 of about 16,768,241 (334)

Long COVID: General Perceptions and Challenges in Diagnosis and Management

On 11 March 2020, the World Health Organization (WHO) declared a pandemic caused by SARS-CoV-2, raising global health concerns. Reports of persistent and new symptoms following the acute phase of infection highlighted the complexities of recovery and ...
Katia Ozanic, Vanessa Cordeiro Dias, Aripuana Sakurada Aranha Watanabe, Alesandra Barbosa Ferreira Machado, Vania Lucia da Silva, Claudio Galuppo Diniz   +5 more
core   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Association of circulating biomarkers with illness severity measures differentiates myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID-19 condition: a prospective pilot cohort study

Journal of Translational Medicine
Background Accumulating evidence suggests that autonomic dysfunction and persistent systemic inflammation are common clinical features in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID.
Joan Carles Domingo, Federica Battistini, Begoña Cordobilla, Maria Cleofé Zaragozá, Ramón Sanmartin-Sentañes, Jose Alegre-Martin, Trinitat Cambras, Jesus Castro-Marrero   +7 more
doaj   +1 more source

Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment

Nature Neuroscience
Vascular disruption has been implicated in coronavirus disease 2019 (COVID-19) pathogenesis and may predispose to the neurological sequelae associated with long COVID, yet it is unclear how blood–brain barrier (BBB) function is affected in these ...
C. Greene, Ruairi Connolly, Declan Brennan, A. Laffan, Eoin O’Keeffe, Lilia Zaporojan, Jeffrey O’Callaghan, Bennett Thomson, Emma Connolly, Ruth Argue, James F. M. Meaney, I. Martín-Loeches, A. Long, C. N. Cheallaigh, N. Conlon, Colin P. Doherty, Matthew Campbell   +16 more
semanticscholar   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2

Nature Immunology
Long COVID (LC) occurs after at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used ‘omic” assays and serology to deeply characterize the global and SARS-CoV-2-specific
Kailin Yin, M. Peluso, Xiaoyu Luo, Reuben Thomas, Min-Gyoung Shin, J. Neidleman, Alicer K. Andrew, Kyrlia C. Young, Tongcui Ma, R. Hoh, K. Anglin, Beatrice Huang, Urania Argueta, Monica Lopez, Daisy Valdivieso, Kofi Asare, Tyler-Marie Deveau, S. Munter, Rania Ibrahim, L. Ständker, Scott Lu, S. A. Goldberg, Sulggi A. Lee, Kara L. Lynch, J. Kelly, Jeffrey N. Martin, Jan Münch, S. Deeks, T. Henrich, N. Roan, Nature Immunology Letter   +30 more
semanticscholar   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

What Can We Learn Four Years On? A Multi‐Centre Service Evaluation Exploring Symptoms, Functional Impact, Recovery and Care Pathways in Long Covid

Health Expectations
Background Long Covid (LC) is associated with long‐term health impacts that require ongoing support from healthcare services. We aimed to gain insights into patients' perceptions of their ongoing symptoms of LC, the effect on daily living and vocation ...
Cassie Lee, Paul Williams, Amiad Abrahams, Julie Darbyshire, Helen E. Davies, Johannes De Kock, Umut Esmer, Samantha A. Jones, Vicky Newey, Janet Scott, Nikki Smith, Darren Winch, Harsha Master, Sarah Elkin, LOCOMOTION Consortium   +14 more
doaj   +1 more source

The effectiveness of COVID-19 vaccines to prevent long COVID symptoms: staggered cohort study of data from the UK, Spain, and Estonia.

The Lancet Respiratory Medicine
BACKGROUND Although vaccines have proved effective to prevent severe COVID-19, their effect on preventing long-term symptoms is not yet fully understood.
M. Català, N. Mercadé-Besora, Raivo Kolde, N. T. Trinh, E. Roel, E. Burn, Trishna Rathod-Mistry, K. Kostka, W. Y. Man, A. Delmestri, H. Nordeng, A. Uusküla, T. Duarte-Salles, Daniel Prieto-Alhambra, A. Jödicke   +14 more
semanticscholar   +1 more source

Long COVID Is Associated with Severe Cognitive Limitations Among U.S. Adults

Long COVID is characterized by persistent symptoms following the resolution of an acute COVID-19 infection. Long COVID may affect cognition due to possible ischemia, neuro-inflammation, and hypoxia related to COVID-19.
Iman Mohamed, Jahnavi Pinnamraju, Theodora Iwudibia, Rolake Neba, Usha Sambamoorthi   +4 more
core   +1 more source