Results 31 to 40 of about 111,624 (298)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Study on the suspending mechanism of gangue particle in coal-based solid waste slurry
Alexandria Engineering JournalIn China's coal mine backfill mining projects, certain mines demonstrate an extensive filling distance that exceeds 3000 m. However, there are few researches concerning the theoretical underpinnings for slurry long-distance pipeline transportation ...
Tao Li +4 more
doaj +1 more source
Surge Tank Analysis for Water Hammer Remedy for Long Distance Pipeline
Diyala Journal of Engineering Sciences, 2018 Various protection methods can be used for protecting the pipeline system from the impact of water hammer. Which includes the use of special materials for supporting the pipeline and the installation of special devices such as surge tanks, relief valves,
Nisreen J. Rasheed , Qassem H. Jalut
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Energy Science & Engineering, 2023 The transportation of hydrogen is a weak link in the large‐scale development of the hydrogen energy industry. Injecting hydrogen into the natural gas pipeline network for transportation is an efficient way to achieve the large‐scale, long‐distance, and ...
Shuangjie Yan +5 more
doaj +1 more source
Calculation method for cutting quantity of long-distance pipeline butt joint
You-qi chuyun, 2022 During the laying of long-distance pipelines, pipe butt is always one of the construction difficulties faced by the field technicians, and accurately drawing the cutting trajectory is the key to improve the quality and efficiency of pipe butt.Therefore ...
Yukun LI +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Design of overpressure protection system for long-distance grouting pipeline
Gong-kuang zidonghua, 2014 In view of problem that existing mine grouting system cannot protect pipeline real-timely when pressure is too large, the paper proposed design scheme of overpressure protection system for long-distance grouting pipeline based on PLC.
LIU Lei, WANG Weifeng
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source