Results 31 to 40 of about 7,997,939 (277)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Study on the suspending mechanism of gangue particle in coal-based solid waste slurry
Alexandria Engineering JournalIn China's coal mine backfill mining projects, certain mines demonstrate an extensive filling distance that exceeds 3000 m. However, there are few researches concerning the theoretical underpinnings for slurry long-distance pipeline transportation ...
Tao Li +4 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2017 In this paper, a procedure is developed to analyze long-distance free-spanning pipelines on an uneven seabed through the incorporation of the Vector Form Intrinsic Finite Element (VFIFE or V-5) method with the bubble model, which is also called the ...
林缅 +2 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Synthetic Analysis and Research of Pipeline Optical Cable Signal in Different Terrain
Guangtongxin yanjiu, 2022 Pipeline cable in southwest mountainous areas goes through many complex areas (mountains, rivers, tunnels, farmland, etc.). By geological deformation, man-made damage often leads to fiber core broken, and seriously affects the safety of pipeline ...
CAO Wen-chen +8 more
doaj +3 more sources
Energies, 2018 For a long-distance pipeline, the seismic load is a four-dimensional space-time excitation that simultaneously changes with time and space. In this work, a novel random space-time seismic model is established for a long-distance pipeline, which uses the ...
Peng Zhang, Yihuan Wang, Guojin Qin
doaj +1 more source
Calculation method for cutting quantity of long-distance pipeline butt joint
You-qi chuyun, 2022 During the laying of long-distance pipelines, pipe butt is always one of the construction difficulties faced by the field technicians, and accurately drawing the cutting trajectory is the key to improve the quality and efficiency of pipe butt.Therefore ...
Yukun LI +6 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source