Results 41 to 50 of about 7,997,939 (277)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Review of hydrogen transmission pipeline technology development

You-qi chuyun
Objective Hydrogen energy stands out as a widely utilized and ecologically sustainable fuel source, renowned for its cleanliness, high efficiency, diverse sources, and renewability.
Debao CHENG, Jiangang LIN, Naiteng WEI, Wenxia YU, Chunlei DANG, Huafeng TIAN   +5 more
doaj   +1 more source

Computational fluid dynamic analysis of hydrogen‐injected natural gas for mixing and transportation behaviors in pipeline structures

Energy Science & Engineering, 2023
The transportation of hydrogen is a weak link in the large‐scale development of the hydrogen energy industry. Injecting hydrogen into the natural gas pipeline network for transportation is an efficient way to achieve the large‐scale, long‐distance, and ...
Shuangjie Yan, Guanwei Jia, Weiqing Xu, Rui Li, YangHui Lu, Maolin Cai   +5 more
doaj   +1 more source

Interpretation of surveying and mapping geographic information policies for long-distance pipelines and countermeasures for application

You-qi chuyun, 2021
Due to the national requirements for keeping the surveying and mapping geographic information confidential, the sharing of long-distance pipeline coordinate data is always a difficulty for the application of informatization of the pipeline operators ...
Bao-long YANG, Wu REN, Hai-kang GAO, Xin-jian ZHANG, Yun-ting MU   +4 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Assessing the congestion cost of gas pipeline between China and Russia

Energy Strategy Reviews
Determining transportation routes is of great importance for advancing China-Russian gas cooperation, which has been hanging in the balance. This paper employs a general equilibrium model to assess the congestion cost of diversified gas transmission ...
Qi Wei, Peng Zhou, Xunpeng Shi
doaj   +1 more source

Study and Analysis on Stress Safety Judgment Method of Heavy Vehicle Rolling on Long-Distance Pipeline

Geofluids, 2022
With the rapid increasing mileage of China’s long-distance oil and gas pipelines, the intersection construction with other civil engineering, encroachment by invading the pipeline route, and other third-part problems occurred occasionally. Heavy vehicles
Ning Shi, Jinxu Jiang, Lin Geng, Liwen Zhang, Yakun Niu, Kaimeng Wang   +5 more
doaj   +1 more source

Wireless Sensor Networks For Long Distance Pipeline Monitoring

, 2013
The main goal of this seminal paper is to introduce the application of Wireless Sensor Networks (WSN) in long distance infrastructure monitoring (in particular in pipeline infrastructure monitoring) – one of the on-going research projects by the Wireless Communication Research Group at the department of Electronic and Computer Engineering, Nnamdi ...
Augustine C. Azubogu, Victor E. Idigo, Schola U. Nnebe, Obinna S. Oguejiofor, Simon E.   +4 more
openaire   +2 more sources