Results 41 to 50 of about 11,890,366 (254)

Behavior of square concrete‐filled steel tubular beam‐columns subjected to lateral loads with constant cyclic displacement

open access: yesJapan Architectural Review, 2021
The objective of this study was to clarify the cyclic behavior of square concrete‐filled steel tube (CFT) beam‐columns subjected to lateral loads with constant cyclic displacement under constant axial load.
Masae Kido   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Base isolation system with negative stiffness for displacement mitigation under long-period and near-fault ground motions [PDF]

open access: yes, 2020
埼玉大学博士(学術)1 v.Base isolation technique is one of the most widely accepted design philosophy for earthquake resistant design of both the large-scale structures and small-scale structures such as sensitive instruments, cultural assets, furniture, and art ...
ネパール, サンディア   +1 more
core   +1 more source

Finite Difference Method-Based Critical Ground Motion and Robustness Evaluation for Long-Period Building Structures Under Uncertainty in Fault Rupture

open access: yesFrontiers in Built Environment, 2019
It is known that, while the stochastic Green's function method is suitable for generating ground motions with short periods, the three-dimensional finite difference method (FDM) is appropriate for ground motions with rather long periods.
Koki Makita   +2 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Local and global effects of forward directivity

open access: yesGrađevinar, 2013
Previous studies have revealed that near-fault ground motions perpendicular to the fault slip are very destructive for structures. Due to the common use of moment resisting frames and the importance of near-fault strong motions, the local and global ...
Mohsen Gerami, Davood Abdollahzadeh
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Long-period earthquake ground displacements recorded on Guadeloupe (French Antilles) [PDF]

open access: yes, 2007
Displacement time-histories derived from accelerograms of three recent earthquakes in western North America (Hector Mine, Mw 7.1; Denali, Mw 7.9; and San Simeon, Mw 6.5) have been shown to feature large long-period (∼10 s) ground-motion cycles. Such long-
Jousset, Philippe   +5 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

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