Results 121 to 130 of about 7,939,670 (409)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Understanding the impact of supervision on reducing medication risks: an interview study in long-term elderly care

open access: yesBMC Health Services Research, 2017
Background In 2009, the Dutch Health Care Inspectorate (IGZ) observed several serious risks to safety involving medication within elderly care facilities. However, by 2011, high risks had been reduced in almost all the organisations we visited.
J. A. Vermeulen   +3 more
doaj   +1 more source

Measuring social protection for long-term care

open access: yes, 2017
This report presents the first international quantification and comparison of levels of social protection for long-term care (LTC) in 14 OECD and EU countries.
T. Muir
semanticscholar   +1 more source

Annual report, 2008 [PDF]

open access: yes, 2008
Each year the South Carolina Long Term Care Ombudsman Program produced an annual report with a brief history, purpose of the program, quick facts and directory of programs with telephone ...
South Carolina Long Term Care Ombudsman Program
core  

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Long-Term-Care Utility and Late-in-Life Saving

open access: yesJournal of Political Economy, 2015
Older wealth holders spend down assets much more slowly than predicted by classic life-cycle models. This paper introduces health-dependent utility into a model with incomplete markets in which preferences for bequests, expenditures when in need of long ...
J. Ameriks   +4 more
semanticscholar   +1 more source

2011 Annual report [PDF]

open access: yes, 2011
Each year the South Carolina Long Term Care Ombudsman Program produced an annual report with a brief history, purpose of the program, quick facts and directory of programs with telephone ...
South Carolina Long Term Care Ombudsman Program
core  

Long-term condition management in adults with intellectual disability in primary care: a systematic review [PDF]

open access: yes, 2018
Background: Adults with intellectual disabilities have higher morbidity and earlier mortality than the general population. Access to primary health care is lower, despite a higher prevalence of many long-term conditions.
Allan, Linda   +4 more
core   +1 more source

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