Results 121 to 130 of about 17,101,780 (300)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Predictors of Actual Turnover Among Part‐Time Homecare Nurses in Japan: A Longitudinal Study

Journal of General and Family Medicine
Background High turnover among homecare nurses leads to nursing shortages and a decline in care quality. In Japan, part‐time nurses are crucial to the workforce.
Maiko Noguchi‐Watanabe, Noriko Yamamoto‐Mitani, Hanako Numata, Asa Inagaki‐Asano   +3 more
doaj   +1 more source

Study of predictors of mortality among older residents with pneumonia in Qatar's long-term care facilities

Aging and Health Research
It is widely recognized that older adults are at an increased risk of contracting pneumonia, which may lead to significant adverse outcomes, including increased rates of morbidity and mortality. The primary aim of this retrospective study was to identify
Shafi Hashmath Ulla Khan, Al Anoud Al Fehaidi, Wasim Akram, Irshad Badarudeen, Mahmoud Ahmed Refaee, Noorudeen Kunnunmal, Asma Abbas, Osama Idris, Sheela Umakanth, Hanadi Al Hamad   +9 more
doaj   +1 more source

Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2009
L. Epstein, D. Kristo, P. Strollo, N. Friedman, A. Malhotra, S. Patil, K. Ramar, R. Rogers, R. Schwab, E. M. Weaver, M. Weinstein   +10 more
semanticscholar   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Long Term Care Ombudsman Annual Report, 1994

, 1994
October 1, 1993, to September 30 ...
Kansas. Long Term Care Ombudsman
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Analysis of outcomes from a geriatrician-led evidence-based falls prevention clinic: a retrospective study from Qatar

The Aging Male
Background Falls are an important health concern among older persons. This study attempted to evaluate the characteristics and risk factors of falls in older persons attending a geriatric falls clinic in Qatar, with a particular emphasis on the impact of
Hanadi Al Hamad, Brijesh Sathian
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source