Results 101 to 110 of about 476,218 (260)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Evolution of Microstructure and Mechanical Properties of Steam Generator Material After Long-Term Operation in Nuclear Power Plant

Metals
The microstructural evolution and mechanical properties of WWER 440 steam generator steel GOST 22K after long-term operation were thoroughly examined in this study. The samples were taken directly from a steam generator using the small punch test method.
David Slnek, Mária Dománková, Marek Adamech, Jana Petzová, Katarína Bártová, Marek Kudláč, Matúš Gavalec   +6 more
doaj   +1 more source

Experimental and Numerical Analysis of 60-Year-Old Sluice Gate Affected by Long-Term Operation. [PDF]

Materials (Basel), 2020
Pástor M, Bocko J, Lengvarský P, Sivák P, Šarga P.   +4 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Long-term Long Term Evaluation of Operation and Design of the Emmaboda BTES. : Operation and Experiences 2010-2015

, 2016
The large-scale borehole layer (BTES) in Emmaboda was commissioned in 2010. Its aim was to make use of waste heat from the industrial processes at the Xylem plant. During all the years since its inception, additional heat sources have been included, and only now can the predicted annually amount of stored heat (3.6 GWh/year) be achieved.
Nordell, Bo, Scorpo, Alberto Liuzzo, Andersson, Olle, Rydell, Leif, Carlsson, Björn   +4 more
openaire   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Desorption from Hot Scandate Cathodes: Effects on Vacuum Device Interior Surfaces after Long-Term Operation. [PDF]

Materials (Basel), 2020
Seif MN, Balk TJ, Beck MJ.
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Enhancing long-term comprehensive operation of cascade hydropower system using an improved multi-objective RIME optimization

Scientific Reports
For cascade hydropower system (CHS), multi-objective long-term comprehensive operation (MOLTCO) is important for balancing the conflicting objectives of hydropower production and ecological sustainability.
Aolin Gao, Hu Hu, He Li, Lyuwen Su, Zhe Yang, Kaixu Geng, Cihang Shan   +6 more
doaj   +1 more source