Results 81 to 90 of about 476,218 (260)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Comparative investigation of PFAS adsorption onto activated carbon and anion exchange resins during long-term operation of a pilot treatment plant. [PDF]

Water Res, 2022
Chow SJ, Croll HC, Ojeda N, Klamerus J, Capelle R, Oppenheimer J, Jacangelo JG, Schwab KJ, Prasse C.   +8 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Two-Stage System Based on a Software-Defined Radio for Stabilizing of Optical Frequency Combs in Long-Term Experiments

Sensors, 2014
A passive optical resonator is a special sensor used for measurement of lengths on the nanometer and sub-nanometer scale. A stabilized optical frequency comb can provide an ultimate reference for measuring the wavelength of a tunable laser locked to the
Martin Čížek, Václav Hucl, Jan Hrabina, Radek Šmíd, Břetislav Mikel, Josef Lazar, Ondřej Číp   +6 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

STUDY OF CHARACTERISTICS OF MECHANICAL PROPERTIES OF GAS-DISTRIBUTING STATION PIPES METAL AFTER LONG-TERM OPERATION

Известия высших учебных заведений: Нефть и газ, 2015
During operation the technological pipelines of gas-distributing station are affected by mechanical static loading resulted from internal pressure of gas in the high pressure pipelines and a dynamic loading from a high-speed stream of gas in low pressure
I. Yu. Bykov, I. N. Birillo, P. A. Kuzbozhev   +2 more
doaj   +1 more source

Effect of applied voltage on membrane fouling in the amplifying anaerobic electrochemical membrane bioreactor for long-term operation. [PDF]

RSC Adv, 2021
Cao M, Zhang Y, Zhang Y.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Operational Robustness Assessment of the Hydro-Based Hybrid Generation System under Deep Uncertainties

Energies
The renewable-dominant hybrid generation systems (HGSs) are increasingly important to the electric power system worldwide. However, influenced by uncertain meteorological factors, the operational robustness of HGSs must be evaluated to inform the ...
Jianhua Jiang, Bo Ming, Qiang Huang, Qingjun Bai   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source