Results 51 to 60 of about 10,265,480 (250)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Long Term Care Ombudsman Annual Report 1993

open access: yes, 1993
October, 1992 through September 30 ...
Kansas. Long Term Care Ombudsman
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Stress Testing Hydropower Operation Under Variable Renewable Energy Integration: Potential Impacts and Dynamically Adaptive Strategies

open access: yesWater Resources Research
Hydropower with reservoir offers a compelling combination of stability and flexibility services for regional socio‐economic development and power system.
Xiaoyu Jin   +5 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Interfacial bonding enhancement of the RTV recoating with sandwiched contaminant by plasma jet

open access: yesHigh Voltage, 2019
Room temperature vulcanised (RTV) silicone rubber is widely used in electrical power system, applied to the glass or porcelain insulator surface to enhance insulation.
Shanshan Wang   +6 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Salt Precipitation in Zero‐Gap CO2 Membrane Electrode Assemblies: Strategies for Long‐Term Operation

open access: yesChemElectroChem
Membrane electrode assembly (MEA)‐based CO2 electrolyzers enable high‐rate electrochemical CO2 reduction reaction (CO2RR) with industrially relevant current densities, but their durability is often limited by salt precipitation and electrode flooding ...
Ziling Zhang   +6 more
doaj   +1 more source

Long-Term Optimal Scheduling of Hydro-Photovoltaic Hybrid Systems Considering Short-Term Operation Performance

open access: yesEnergies
Integrating photovoltaic power stations into large-capacity hydropower stations is an efficient and promising method for regulating large-scale photovoltaic power generation.
Wenlin Yuan, Zhangchi Sun
doaj   +1 more source

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