Results 151 to 160 of about 1,220,900 (264)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Impact of Hip Arthroscopy on Long-term Performance Trajectories in NHL Players: A Matched Cohort Study Using Advanced Analytics. [PDF]

Orthop J Sports Med
Bouchard MD, Hayes E, Skaik K, Vivekanantha P, Theodoropoulos J, Ayeni OR.   +5 more
europepmc   +1 more source

Effect of Stabilized Martensite on the Long-Term Performance of Superelastic NiTi Endodontic Files. [PDF]

Materials (Basel), 2023
Sánchez P, Vidi B, Mena-Alvarez J, Gil J, Rico C, Aragoneses JM.   +5 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Interface Evolution and Long-Term Performance of Negative Carbon Fiber Structural Electrodes. [PDF]

ACS Omega
Schneider LM, Sochor B, Johansen M, Liu F, Lindbergh G, Zenkert D, Roth S, Koyiloth Vayalil S, Lebret L.   +8 more
europepmc   +1 more source

The Effect of Welding Defects on the Long-Term Performance of HDPE Pipes. [PDF]

Polymers (Basel), 2022
Lai H, Fan D, Liu K.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Long-Term Performance of Feldspathic and Lithium Disilicate Restorations in Pediatric Anterior Dental Trauma. [PDF]

Children (Basel)
Mihali SG, Talpoș Ș, Loloș D, Loloș BA, Hojda AR, Mitariu L.   +5 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Evaluation of Long-Term Performance of Six PM_2.5 Sensor Types. [PDF]

Sensors (Basel)
Barkjohn KK, Yaga R, Thomas B, Schoppman W, Docherty KS, Clements AL.   +5 more
europepmc   +1 more source