Results 71 to 80 of about 10,105,014 (311)
Improving Long‐Term Glucose Prediction Accuracy with Uncertainty‐Estimated ProbSparse‐Transformer
Advanced Intelligent SystemsAccurate prediction of blood glucose (BG) with precise data recorded by continuous glucose monitoring (CGM) is essential to improve the safety of closed‐loop insulin delivery systems for diabetic patients.
Wei Huang +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An LSTM-Based Method with Attention Mechanism for Travel Time Prediction
Sensors, 2019 Traffic prediction is based on modeling the complex non-linear spatiotemporal traffic dynamics in road network. In recent years, Long Short-Term Memory has been applied to traffic prediction, achieving better performance.
Xiangdong Ran +3 more
doaj +1 more source
Network-Based Layered Architecture for Long-Term Prediction
IEEE Access, 2020 In time series forecasting, a challenging and important task is to realize long-term prediction. This paper proposes a layered architecture based on backpropagation neural network. The proposed layered architecture consists of two layers. The first layer
Weina Wang, Kai Lin, Jinxing Zhao
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Economics of long-term care in Ohio
, 1992 Electronic data (1 file : 445123 bytes).; "Ohio Long-Term Care Research Project"--Cover.; Includes bibliographical references (p.
Mehdizadeh, Shahla A. +1 more
core
Proposed framework for short-term, mid-term and long-term mortality prediction tasks.
, 2022 Proposed framework for short-term, mid-term and long-term mortality prediction tasks.
Maria Mahbub (11914235) +6 more
core +1 more source
Predicting long-term outcome in renal transplantation [PDF]
Kidney International, 2013 Long-term outcome in renal transplantation is heterogeneous, and predicting success is challenging. Astor and colleagues report that serum β2M levels measured on discharge after transplantation correlate closely with long-term patient and graft survival, and may serve as a biomarker of clinical risk.
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source