Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
Workplace Bullying and Long-Term Sickness Absence-A Five-Year Follow-Up Study of 2476 Employees Aged 31 to 60 Years in Germany. [PDF]
Int J Environ Res Public Health, 2022 Burr H, Balducci C, Conway PM, Rose U.
europepmc +1 more source
Genetic Code Expanded T Cell for Controllable Immunotherapy
Advanced Science, EarlyView.Our GCE‐CAR‐T cells enables tight, dose‐dependent, and function‐preserving control of CAR expression at the translational level through amber codon suppression and genetic incorporation of ncAA. ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy has demonstrated curative potential against hematologic malignancies, but its clinical application ...
Xue Wang +4 more
wiley +1 more source
Do different job demands interact as predictors of long-term sickness absence? A register-based follow-up on 55 467 Danish workers. [PDF]
Occup Environ Med, 2023 Clausen T +4 more
europepmc +1 more source
Advanced Science, EarlyView.Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu +7 more
wiley +1 more source
Can leadership quality buffer the association between emotionally demanding work and risk of long-term sickness absence? [PDF]
Eur J Public Health, 2021 Rugulies R +5 more
europepmc +1 more source
Conformal Reconfigurable Intelligent Surfaces: A Cylindrical Geometry Perspective
Advanced Electronic Materials, EarlyView.Cylindrical reconfigurable intelligent surfaces are explored for low‐complexity beam steering using one‐bit meta‐atoms. A multi‐level modeling approach, including optimization‐based synthesis, demonstrates that even minimal hardware can support directive scattering.
Filippo Pepe +4 more
wiley +1 more source
Chronic disorders, work-unit leadership quality and long-term sickness absence among 33 025 public hospital employees. [PDF]
Scand J Work Environ Health, 2022 Mehta AJ +4 more
europepmc +1 more source
Comparative Insights and Overlooked Factors of Interphase Chemistry in Alkali Metal‐Ion Batteries
Advanced Energy Materials, EarlyView.This review presents a comparative analysis of Li‐, Na‐, and K‐ion batteries, focusing on the critical role of electrode–electrolyte interphases. It especially highlights overlooked aspects such as SEI/CEI misconceptions, binder effects, and self‐discharge relevance, emphasizing the limitations of current understanding and offering strategies for ...
Changhee Lee +3 more
wiley +1 more source
Metabolic Syndrome and the Increased Risk of Medically Certified Long-term Sickness Absence: A Prospective Analysis Among Japanese Workers. [PDF]
J Epidemiol, 2023 Hoang DV +29 more
europepmc +1 more source