Results 111 to 120 of about 8,205,191 (295)

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

Long COVID and Health Inequalities: What's Next for Research and Policy Advocacy?

Health Expectations
Introduction Organised by the ‘Qualitative Long Covid Network’, a workshop for qualitative Long COVID (LC) researchers, LC charity representatives and people with LC took place in June 2023, where research on the intersectional inequalities affecting LC ...
Sarah Akhtar Baz, Mirembe Woodrow, Donna Clutterbuck, Chao Fang, Jordan Mullard, Amitava Banerjee, Sarah Barley‐McMullen, Jd Carpentieri, Anne‐Laure Donskoy, Alice Faux‐Nightingale, Sasha Lewis‐Jackson, Margaret E. O'Hara, Tanvi Rai, Ondine Sherwood, Nina Smyth, Kirsty Stanley, Victoria Welsh, Ghazala Mir, Nisreen A. Alwan   +18 more
doaj   +1 more source

Who Is the Intermediate Host of RNA Viruses? A Study Focusing on SARS-CoV-2 and Poliovirus

Microorganisms
The COVID-19 pandemic has sparked a surge in research on microbiology and virology, shedding light on overlooked aspects such as the infection of bacteria by RNA virions in the animal microbiome.
Carlo Brogna, Domenico Rocco Bisaccia, Vincenzo Costanzo, Gennaro Lettieri, Luigi Montano, Valentina Viduto, Mark Fabrowski, Simone Cristoni, Marina Prisco, Marina Piscopo   +9 more
doaj   +1 more source

Long COVID as a Possible Contributor to Rising Suicide Mortality in Bharat (India): An Analysis of Suicide Trends Since the Emergence of COVID-19

Mortality due to suicide is amongst the largest public health concerns across the world today in Bharat (India). There have been concerns that the COVID-19 pandemic has contributed to worsening mental health outcomes across the world, including in Bharat.
Mansoor Ahmed Panhwar, Karan Varshney
core   +1 more source

Hydro‐ and Lipophilicity of Molecular‐Size‐Controlled Hydrogel Drug Carriers

Advanced Materials Technologies, EarlyView.
We investigate nano‐sized hydrogel drug carriers with tailored hydro‐ and lipophilicity. We design their encapsulation and structure‐forming capabilities and follow them in real time during fabrication using time‐resolved and in situ grazing incidence x‐ray scattering.
Elisabeth Erbes, Naireeta Biswas, Calvin J. Gavillet, Matthias Schwartzkopf, Krishnayan Basuroy, Qing Chen, Andrei Chumakov, Susann Frenzke, Marc Gensch, Korneliya Gordeyeva, Patrycja Kielb, Sonja Kirchner, Volker Körstgens, Peter Müller‐Buschbaum, Henrike M. Müller‐Werkmeister, Jan Rubeck, Sreevidya Thekku Veedu, Jose de Jesus Velazquez‐Garcia, Vivian Waclawek, Daniel Söderberg, Stephan V. Roth, Simone Techert   +21 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Exploring long COVID in pediatric patients: clinical insights from a long COVID clinic

Frontiers in Pediatrics
BackgroundLong COVID describes the persistence or recurrence of symptoms beyond the acute phase of SARS-CoV-2 infection and is increasingly recognized in children and adolescents.
Dina Kamel, Dina Kamel, My H. Vu, Jeffery Bender, Jeffery Bender, David Warburton, John C. Wood, John C. Wood, Sindhu Mohandas, Sindhu Mohandas   +9 more
doaj   +1 more source

A long journey to long COVID

The Lancet Respiratory Medicine, 2023
openaire   +2 more sources

Coronavirus disease 2019 (COVID-19) : update and information for long-term care facilities [PDF]

Date: Tuesday, March 17, 2020Time: 2:00 P.M. \u2013 3:00P.M. (Eastern Time)During this COCA Call, presenters will focus on current information about COVID-19 as it relates to long-term care facilities, including nursing homes.

core