Results 131 to 140 of about 16,187 (162)

Long interspersed nucleotide element-1 (LINE-1) methylation in colorectal cancer

Clinica Chimica Acta, 2019
Colorectal cancer (CRC) represents a group of molecularly heterogeneous diseases characterized by genetic and epigenetic alterations. Long interspersed nuclear elements (LINEs) are a form of retrotransposable element found in many eukaryotic genomes. These LINEs, when active, can mobilize in the cell and steadily cause genomic rearrangement.
Mohammad Amin Kerachian, Matin Kerachian
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Long interspersed nucleotide element‐1 hypomethylation in folate‐deficient mouse embryonic stem cells

Journal of Cellular Biochemistry, 2013
AbstractFolate is thought to contribute to health and development by methylation regulation. Long interspersed nucleotide element‐1 (LINE‐1), which is regulated by methylation modification, plays an important role in sculpting the structure and function of genomes.
Shaoyan, Chang, Li, Wang, Yunqian, Guan, Shaofang, Shangguan, Qingan, Du, Yang, Wang, Ting, Zhang, Yu, Zhang   +7 more
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Long Interspersed Nucleotide Element 1 Hypomethylation Is Associated With Poor Prognosis of Lung Adenocarcinoma

The Annals of Thoracic Surgery, 2013
Genome-wide DNA hypomethylation is known to play important roles in genomic instability and carcinogenesis. Methylation in long interspersed nucleotide element 1 (LINE-1) is a good indicator of the global DNA methylation level within a cell. The aim of this study was to evaluate prognostic significance of LINE-1 hypomethylation in lung adenocarcinoma.A
Koei, Ikeda, Kenji, Shiraishi, Ayami, Eguchi, Hidekatsu, Shibata, Kentaro, Yoshimoto, Takeshi, Mori, Yoshifumi, Baba, Hideo, Baba, Makoto, Suzuki   +8 more
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Tumor Long-interspersed Nucleotide Element-1 Methylation Level and Immune Response to Esophageal Cancer

Annals of Surgery, 2019
Objective: To examine the relationship between tumor long-interspersed nucleotide element-1 (LINE-1) methylation level and immune response to esophageal cancer. Background: Evidence points to a correlation between the abundance of immune cells and a favorable prognosis in esophageal
Keisuke, Kosumi, Yoshifumi, Baba, Kazuo, Okadome, Taisuke, Yagi, Yuki, Kiyozumi, Naoya, Yoshida, Masayuki, Watanabe, Hideo, Baba   +7 more
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Hypomethylation of long interspersed nucleotide element‐1 in peripheral mononuclear cells of juvenile systemic lupus erythematosus patients in China

International Journal of Rheumatic Diseases, 2013
AbstractAimMethylation abnormalities in T lymphocytes have been reported to correlate with systemic lupus erythematosus (SLE). Previous studies identified hypomethylation in the promoter of several genes linked to SLE. Long interspersed nucleotide element‐1 (LINE‐1) constitutes 17–25% of the human genome, and LINE‐1 hypomethylation has been reported in
Xiaolan, Huang, Gaixiu, Su, Zhen, Wang, Shaofang, Shangguan, Xiaodai, Cui, Jia, Zhu, Min, Kang, Shengnan, Li, Ting, Zhang, Fengqi, Wu, Li, Wang   +10 more
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Length distribution of long interspersed nucleotide elements (LINEs) and processed pseudogenes of human endogenous retroviruses: implications for retrotransposition and pseudogene detection

Gene, 2002
Deciphering the human genome includes reliable identification and structural characterization of individual retrotransposon elements. The most active group of autonomous transposable elements, the long interspersed nuclear elements (LINE), transpose themselves as well as other RNAs, including those of human endogenous retroviruses (HERV).
Adam, Pavlícek, Jan, Paces, Radek, Zíka, Jirí, Hejnar   +3 more
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Tissue-Specific Methylation of Long Interspersed Nucleotide Element-1 of Homo Sapiens (L1Hs) During Human Embryogenesis and Roles in Neural Tube Defects

Current Molecular Medicine, 2015
Epigenetic regulation of long interspersed nucleotide element-1 (LINE-1) retrotransposition events plays crucial roles during early development. Previously we showed that LINE-1 hypomethylation in neuronal tissues is associated with pathogenesis of neural tube defect (NTD).
L, Wang, S, Chang, J, Guan, S, Shangguan, X, Lu, Z, Wang, L, Wu, J, Zou, H, Zhao, Y, Bao, Z, Qiu, B, Niu, T, Zhang   +12 more
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Association of long interspersed nucleotide element‐1 and interferon regulatory factor 6 methylation changes with nonsyndromic cleft lip with or without cleft palate

Oral Diseases, 2018
AbstractObjectiveTo examine the possible associations between methylation changes in the promoter regions of long interspersed nucleotide element‐1 (LINE‐1) and interferon regulatory factor 6 gene (IRF6) and nonsyndromic cleft lip with or without cleft palate (NSCL/P).MethodsA case–control investigation was performed to compare 37 infants affected by ...
Yanhua Li, Ying Deng, Changfei Deng, Liang Xie, Li Yu, Lijun Liu, Yumei Yuan, Hanmin Liu, Li Dai   +8 more
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Relationships among one‐carbon nutrients status, DNA methylation at H19 differentially methylated region and the long interspersed nucleotide elements, and serum insulin‐like growth factor levels of pregnant women

The FASEB Journal, 2017
Kwang‐Ta Huang 1,2 , Yu‐Li Shen 3 , Chien‐Nan Lee 4 , Chin‐Pao Cheng 5 , Wei‐Chi Ku 6 , and Rwei‐Fen S. Huang 1,4
Kwang‐Ta Huang, Yu‐Li Shen, Chien‐Nan Lee, Chin‐Pao Cheng, Wei‐Chi Ku, Rwei‐Fen S. Huang   +5 more
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Roles of transposable elements in the regulation of mammalian transcription

Nature Reviews Molecular Cell Biology, 2022
Julius A Judd, Cédric Feschotte, Joanna Wysocka   +2 more
exaly