Results 61 to 70 of about 6,611,752 (262)
Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis
Advanced Science, EarlyView.CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni +11 morewiley +1 more sourceOutcome by Sex in Patients With Long QT Syndrome With an Implantable Cardioverter Defibrillator
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Sex differences in outcome have been reported in patients with congenital long QT syndrome. We aimed to report on the incidence of time‐dependent life‐threatening events in male and female patients with long QT syndrome with an implantable ...Arwa Younis, Mehmet K. Aktas, Spencer Rosero, Valentina Kutyifa, Bronislava Polonsky, Scott McNitt, Nona Sotoodehnia, Peter Kudenchuk, Thomas D. Rea, Dan E. Arking, Ilan Goldenberg, Wojciech Zareba +11 moredoaj +1 more sourceAge‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission
Advanced Science, EarlyView.This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie +12 morewiley +1 more sourceCommon Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies [PDF]
, 2009 To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation associated with risk of ventricular arrhythmias and sudden cardiac death, we conducted a meta-analysis of three genome-wide association studies (GWAS ...Rice, K. (Kenneth), Samani, NJ, Jamshidi, Yalda, Chris Wallace (210182), Tobin, M., Carter, Nicholas D., Panos Deloukas, Sanna, Serena, DCCT EDIC Res Grp, Pfeufer, Arne, Snieder, Harold; id_orcid, Fu, J, Patricia B. Munroe (7588601), de Bakker, PIW, Kenneth Rice, Carter, N.D. (Nicholas), Zheng, DL, Wain, LV, Caulfield, M. (Mark), Fu, Jingyuan, Sanna, S, Arking Dan E., Morris Brown, Steve Jeffery, Andrew D. Paterson, Newhouse, Stephen; id_orcid, Deloukas, P, Fu, J. (Jingyuan), John M. Connell (7588580), Nolte, I.M., Sanna, S., Paul I W de Bakker, Dalageorgou, C., Wallace, C. (Chris), Lathrop, Mark, Serena Sanna, null null, Waggott, D. (Daryl), Rice Kenneth, Ilja M. Nolte, John Connell, QTGEN Consortium, Farrall Martin, Brown, M, Morris Brown (238594), Samani, Nilesh J., de Bakke, Paul I. W., Martin Tobin, Gwilliam, R. (Rhian), Gwilliam Rhian, QTSCD Consortium, Nilesh J. Samani (7579793), Farrall, M, Rhian Gwilliam, Jeffery, S., Wallace Chris, Irina Savelieva (262110), Wallace,C., Arne Pfeufer, Newton-Cheh, Christopher, Harold Snieder (103613), Martin Farrall, Gwilliam, Rhian, Arking, D.E., Soranzo, N, Newhouse, SJ, Jamshidi, YM, Snieder Harold, Louise V. Wain (7588511), Spector, Tim D., Zheng, D. (Dongling), Zeggini, E, Waggott, Daryl, Andrew D Paterson, Fu Jingyuan, Snieder, H., Zheng, Dongling, Newton-Cheh Christopher, Arking, D.E. (Dan), Munroe, PB, de Bakker, Paul I. W., Wallace, C, Arking, DE, Zheng, D., Newton-Cheh, C., Nicholas D. Carter (7588595), Jamshidi Yalda, Fu, Jingyuan; id_orcid, Dongling Zheng, Chris Wallace, Eijgelsheim, Mark, Louise V Wain, Lathrop, M, Caulfield, M., Tim D. Spector (7588592), Zeggini, Eleftheria, Irina Savelieva, Serena Sanna (145737), Stephen J. Newhouse (7588577), Ilja M Nolte, Pfeufer, A., Folkert W. Asselbergs, Daryl Waggott, Zeggini Eleftheria, Carter, N.D., Folkert W Asselbergs, Pfeufer Arne, Dan E Arking, Lathrop, M. (Mark), Wallace, Chris, Mark Eijgelsheim (110185), Samani, N.J., Waggott, D, Mark Eijgelsheim, Stephen J Newhouse, Munroe, P. (Patricia), Harold Snieder, ?, ?, Tobin Martin, Patricia B Munroe, Sanna, Serena; id_orcid, Pfeufer, A, Savelieva, I. (Irina), Gwilliam, R, Soranzo, N., Yalda Jamshidi, Paul I.W. de Bakker (7588583), Mark Lathrop, Fu, JY, Connell, J. (John), Martin D. Tobin (7581161), Chrysoula Dalageorgou, Soranzo, N. (Nicole), Arne Pfeufer (76634), Dominiczak, A, Savelieva, Irina, Rice, Kenneth, Jeffery, Steve, Paterson, Andrew D., The DCCT/EDIC Research Group, Waggott, D., Snieder, H, Steve Jeffery (262137), Wellcome Trust Case Control Consor, Eleftheria Zeggini, Jingyuan Fu, Farrall, M., Bakker, P.I.W. (Paul) de, Patricia B. Munroe, Brown, M., Deloukas Panos, Brown Morris, Fu, J., Spector Tim D., Paterson, AD, Eleftheria Zeggini (21702), Nilesh J. Samani, Jeffery, S, DCCT/EDIC Research Group, Nicholas D Carter, Zeggini, E. (Eleftheria), Rice, K., Savelieva Irina, Farrall, Martin, Wain, L.V., Nolte, Ilja M., Tobin, Martin, Samani Nilesh J., Jamshidi, Y, Newhouse, S.J. (Stephen), Andrew D. Paterson (7588598), Nicole Soranzo (12361), Tim D Spector, Wain, Louise V., Savelieva, I., Spector, T.D. (Timothy), Nolte Ilja M., Nolte, I.M. (Ilja), Rice, K, Ilja M. Nolte (7588574), Martin Farrall (62715), Munroe, Patricia B., Zheng Dongling, Gwilliam, R., Nolte, Ilja M.; id_orcid, Eijgelsheim, M., Soranzo, Nicole, Eijgelsheim, M. (Mark), Eijgelsheim Mark, Paterson Andrew D., Carter Nicholas D., Jingyuan Fu (102399), Savelieva, I, Asselbergs, FW, Sanna Serena, Dan E. Arking, Dalageorgou, Chrysoula, Caulfield, Mark, Jeffery, S. (Steve), Anna Dominiczak (262121), Asselbergs, F.W., Deloukas, P., Pfeufer, A. (Arne), Christopher Newton-Cheh, Newhouse, S.J., Wain, L.V. (Louise), Nicole Soranzo, Farrall, M. (Martin), Paul I. W. de Bakker, Asselbergs, Folkert W., Nicholas D. Carter, Dominiczak, A., Chrysoula Dalageorgou (262115), de Bakker, Paul I.W., Wellcome Trust Case Control Consortium, Yalda Jamshidi (262159), Lathrop Mark, Asselbergs, F.W. (Folkert), Newhouse, Stephen J., Brown, Morris, Caulfield, M, Jamshidi, Y., Dalageorgou, C, Snieder, H. (Harold), Louise V. Wain, Wain Louise V., Dalageorgou, C. (Chrysoula), Munroe, P.B., Brown, M.J. (Morris), Samani, N.J. (Nilesh), Zeggini, E., de Bakker, PI, Caulfield Mark, Anna Dominiczak, Eijgelsheim, M, Jamshidi, Y. (Yalda), Deloukas, Panos, Jeffery, Steve Jeffery, Dominiczak Anna, Tobin, M, Rhian Gwilliam (108263), Newton-Cheh, C, Newhouse Stephen J., Spector, T.D., Folkert W. Asselbergs (7588589), Snieder, Harold, Dongling Zheng (262112), Arking, Dan E., Munroe Patricia B., de Bakker, P.I., Demissie, S. (Serkalem), Dan E. Arking (7588586), Mark J. Caulfield (7588472), Tim D. Spector, Mark Lathrop (17971), Christopher Newton-Cheh (79953), Stephen J. Newhouse, Nolte, IM, Paterson, A.D. (Andrew), Zheng, D, Sanna, S. (Serena), Connell, J, Newton-Cheh, C. (Christopher), Connell John, Jeffery Steve, Tobin, M. (Martin), Mark Caulfield, Panos Deloukas (21564), Carter, ND, de Bakker Paul I. W., Asselbergs Folkert W., Dominiczak, A. (Anna), Soranzo Nicole, Paterson, A.D., Dominiczak, Anna, Spector, TD, Nilesh J Samani, Connell, J., Daryl Waggott (135190), Connell, John, Waggott Daryl, Kenneth Rice (211836), Dalageorgou Chrysoula, de Bakker, Paul, Nolte, IM;Wallace, C;Newhouse, SJ;Waggott, D;Fu, J;Soranzo, N;Gwilliam, R;Deloukas, P;Savelieva, I;Zheng, D;Dalageorgou, C;Farrall, M;Samani, NJ;Connell, J;Brown, M;Dominiczak, A;Lathrop, M;Zeggini, E;Wain, LV;Newton-Cheh, C;Eijgelsheim, M;Rice, K;de Bakker, PI;Pfeufer, A;Sanna, S;Arking, DE;Asselbergs, FW;Spector, TD;Carter, ND;Jeffery, S;Tobin, M;Caulfield, M;Snieder, H;Paterson, AD;Munroe, PB;Jamshidi, Y, Rice, Ken +285 morecore +1 more sourceA Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation
Advanced Science, EarlyView.Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin +16 morewiley +1 more sourcePrecision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks
Advanced Science, EarlyView.This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu +12 morewiley +1 more sourcePhase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis
Hepatology, EarlyView., 2022 Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims
We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou +13 morewiley +1 more source
