Results 161 to 170 of about 7,350,665 (262)

Prenatal exome sequencing of fetuses with central nervous system anomalies based on prenatal ultrasound and magnetic resonance imaging diagnosis: A retrospective cohort study with a systematic review and meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 10, Page 1950-1964, October 2026.
Prenatal exome sequencing significantly improves diagnostic yield over chromosomal microarray analysis for fetal CNS abnormalities, with a diagnostic yield of 16% in our cohort and 27% in the meta‐analysis. Diagnostic yields vary across different phenotypes. Abstract Introduction Fetal central nervous system (CNS) abnormalities have diverse etiologies,
Jia Yao, Yan Wang, Gang Li, Zhitao Zhang, Yuan Lv, Lizhu Chen   +5 more
wiley   +1 more source

NS1643 enhances the activity of T1019PfsX38 and Q1070X hERG channels associated with long QT syndrome type 2. [PDF]

Pflugers Arch
Al Salmani MK, Al Kharusi A, Al Rawahi M, Albarwani S.   +3 more
europepmc   +1 more source

Fruquintinib: Mechanism of Action, Clinical, and Translational Science

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
ABSTRACT Fruquintinib is a highly selective, oral inhibitor of all three vascular endothelial growth factor receptors (‐1, ‐2, and ‐3) that was approved, including in China, the United States, and the European Union, for the treatment of previously treated metastatic colorectal cancer (mCRC).
Xiaofei Zhou, Arvind Dasari, Jin Li, Caly Chien, Qi Dong, Lucy Chen, Lixian Dong, Neeraj Gupta   +7 more
wiley   +1 more source

Updates in COPD Management: From Inflammatory Pathways to Targeted Therapies

European Journal of Clinical Investigation, Volume 56, Issue 10, October 2026.
COPD is a heterogeneous disease driven by overlapping neutrophilic and eosinophilic inflammatory pathways. This review highlights the shift from symptom‐based treatment toward phenotype‐ and biomarker‐directed care. Blood eosinophils, FeNO, and IgE predict corticosteroid responsiveness and identify candidates for biologic therapy.
Sasha Raman, Sreya Rahman, Francesca Polverino, Muhammad Adrish   +3 more
wiley   +1 more source

An Unusual Genetic Variant of Long QT Syndrome with Late Presentation in the Sixth Decade. [PDF]

J Innov Card Rhythm Manag
Pande A, Mukherjee SS, Halder A.
europepmc   +1 more source

Diagnostic performance of SD‐ΔRR during physical stressors for identifying diabetic sensorimotor polyneuropathy

Journal of Diabetes Investigation, Volume 17, Issue 10, Page 1770-1781, October 2026.
Study population, methodology and key findings of the study. ABSTRACT Aims This study aimed to evaluate the clinical efficacy of SD‐ΔRR as a novel methodology for short‐duration heart rate variability (HRV) assessment for the diagnosis of diabetic sensorimotor polyneuropathy (DSPN) in patients with diabetes.
Katsuyoshi Katayama, Haruhito A. Uchida, Toshihiko Nagao, Jun Eguchi, Kenji Tsuji, Yoshinori Matsumoto, Ichiro Nojima, Keiko Tanaka, Hidemi Takeuchi, Yasuhiro Onishi, Rika Takemoto, Satoshi Miyamoto, Kenichi Shikata, Jun Wada   +13 more
wiley   +1 more source

QT Interval Evaluation in Right Ventricular Pacing: Validation of a Novel Formula

Pacing and Clinical Electrophysiology, Volume 49, Issue 10, Page 1455-1463, October 2026.
ABSTRACT Background QT interval measurement in the presence of right ventricular pacing (RVP) represents a clinical challenge. We therefore aimed to derive and validate a formula for QT estimation during RVP in a large cohort of pacemaker patients. Methods and Results We prospectively enrolled 100 patients in a derivation cohort and 487 in a validation
Amr Abdin, Alhasan Almasri, Ibrahim Antoun, Charles Gieres, Christian Werner, Yvonne Bewarder, Christian Ukena, Igor Schwantke, Michael Böhm, Saarraaken Kulenthiran   +9 more
wiley   +1 more source

Factors associated with clinically diagnosed long QT syndrome in Korean adults: a nationwide case-control study. [PDF]

Front Pharmacol
Park DY, Park S, Kwon JW, Song YK.
europepmc   +1 more source

Left Bundle Branch Area Pacing Reverts Electromechanical Window Negativity to a Similar Extent as Biventricular Pacing

Pacing and Clinical Electrophysiology, Volume 49, Issue 10, Page 1464-1472, October 2026.
BiVP = biventricular pacing; CRT = cardiac resynchronization therapy; EMW = electromechanical window; LBBAP = left bundle branch area pacing; QAoC = Time interval from the onset of the QRS complex to the center of the aortic valve closure artifact; QT = QT interval measured by tangent method.
Florien Klein, Metra Daliry, Karin C. Smits, Edoardo Bressi, Peter M. Deissler, Johan van Koll, Jesse H. J. Rijks, Antonius M. W. van Stipdonk, Rachel M. A. ter Bekke, Domenico Grieco, Chiara Manfuro, Giorgia Spiridigliozzi, Annalisa Casalese, Justin G. L. M. Luermans, Frits W. Prinzen, Roel Meiburg, Leonard M. Rademakers, Kevin Vernooy, Uyên Châu Nguyên   +18 more
wiley   +1 more source

Weird, Witty and Worthwhile: Exploring the Benefits of Mnemonic‐Based Medical Education

The Clinical Teacher, Volume 23, Issue 5, October 2026.
ABSTRACT Background Mnemonics, both self‐created and well established, are commonly used by medical students to boost their recall of knowledge. Previous studies have evaluated mnemonics' utility in medical education, but few have demonstrated positive effects on students' knowledge and confidence.
Shazia Sarela, Malvi Shah, Emma Kelley, Nidhi Rege, Harish Bava, Rama Aubeeluck, Elena Boby, Anusha Prabhu   +7 more
wiley   +1 more source