Results 181 to 190 of about 72,610 (277)

Case Report: Perioperative acquired long QT syndrome secondary to severe hypokalemia from duodenal foreign body obstruction in a toddler. [PDF]

Front Med (Lausanne)
Xin J, Wang J, Sun J, Zhang L, Bai X.
europepmc   +1 more source

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Spatial and temporal dispersion of ventricular repolarization in pediatric patients with congenital long QT syndrome. [PDF]

HeartRhythm Case Rep
Dai L, Zhang C, Ramdat Misier NL, van Schie MS, Bear L, Haissaguerre M, Taverne YJHJ, de Groot NMS.   +7 more
europepmc   +1 more source

Clinical Pharmacology and Translational Science Considerations in the Development of Dual‐Payload Antibody Drug Conjugates

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Antibody‐drug conjugates (ADCs) have evolved in the last decade or two from carrying a single chemotherapy payload to carrying highly potent tubulin inhibitors and DNA damaging agents. While the latter have shown success in the clinic, efficacy has been constrained by therapeutic resistance, limited tumor penetration, and suboptimal immune ...
Paulien Ravenstijn, Toru Kakinuma, Salaheldin Hamed, Takeshi Kadokura, Yohei Okada, Srinivasu Poondru   +5 more
wiley   +1 more source

Long QT Syndrome With KCNH2/SCN5A Dual Gene Mutation Leading to Electrical Storm. [PDF]

JACC Case Rep
Ding Q, Lu L, Li S, Guo M.
europepmc   +1 more source

Machine Learning‐Based Prediction of Drug‐Induced QTc Changes in a Large Finnish Biobank Cohort

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Prolongation of the QT interval is a known precursor to serious arrhythmias and sudden cardiac death, often triggered by medication use. Current medication risk evaluation platforms rely on literature‐based synthesis and may lag behind real‐world developments.
Ville Langén, Aleksi Winstén, Konsta Teppo, Timo Pohjonen, Jari Laukkanen, Arto Mannermaa, Teemu J. Niiranen, Joonatan Palmu   +7 more
wiley   +1 more source

Spectrum of genetic variants detected in children tested for long QT syndrome. [PDF]

BMC Cardiovasc Disord
Kemezyte A, Meskiene R, Utkus A, Burnyte B.   +3 more
europepmc   +1 more source

A Scoping Review of Non‐Opioid Therapeutics for Opioid Withdrawal: Translational Relevance to Neonatal Opioid Withdrawal Syndrome (NOWS) Research

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT In the wake of the ongoing opioid epidemic, the incidence of neonatal opioid withdrawal syndrome (NOWS) has surged. While the short‐term effects of NOWS are well‐characterized, long‐term physiological and molecular consequences remain unclear.
Sara L. Mills‐Huffnagle, Oliver M. Lowden, Rhea E. Sullivan, Taryn E. McFadden, Jennifer E. Nyland   +4 more
wiley   +1 more source

Unlocking the Secrets of Andersen-Tawil Syndrome: The Role of Next-Generation Sequencing in a Family With Long QT Syndrome. [PDF]

Cardiol Res Pract
Namazi M, Naderi N, Askarinejad A, Dalili M, Maleki M, Kalayinia S.   +5 more
europepmc   +1 more source

Hashimoto's thyroiditis and congenital long QT syndrome: a dangerous addition causing torsades-case report. [PDF]

Eur Heart J Case Rep
Acharya R, Sabesan V, Pandit D, Schuller D, Tripathi B.   +4 more
europepmc   +1 more source