Results 191 to 200 of about 38,746 (286)

A Prospective Study of Marsh PK‐PD Model and Schnider PK‐PD Model During Anesthesia Induction for Obese Patients Undergoing Elective Heart Surgery

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT This prospective study compared the Marsh and Schnider pharmacokinetic models for propofol target‐controlled infusion (TCI) during anesthetic induction in obese patients undergoing elective cardiac surgery. A total of 118 patients were randomly assigned to either the Marsh or Schnider group (n = 59 each).
Jianhong Ye, Weina Liang
wiley   +1 more source

hERG epitope mimic-decoy peptide corrects autoimmune-long QT syndrome in guinea pigs. [PDF]

Commun Med (Lond)
Cupelli M, Ginjupalli VKM, Reisqs JB, Sleiman Y, Becerra-Flores M, Accioli R, Lazzerini PE, Cardozo T, Boutjdir M.   +8 more
europepmc   +1 more source

Tissue‐retained needles in people who inject drugs: A systematic review of case reports and series on clinical presentations, complications and management

Addiction, Volume 121, Issue 6, Page 1381-1397, June 2026.
Abstract Background and aims Tissue‐retained needles from intravenous drug use can cause rare but severe complications, ranging from local to systemic infections to needle embolization. Due to the limited evidence and the lack of epidemiological studies on the issue, we systematically reviewed the literature focusing on case reports and case series on ...
Heidi Laukkala, Anna Nevalainen, Irina Rinta‐Kiikka, Samuel Heikkilä, Sisu Kiuru, Markku Sumanen, Otso Arponen, Olli Nevalainen   +7 more
wiley   +1 more source

Fetal Bradycardia Prompting the Diagnosis and Management of Parental Long QT Syndrome. [PDF]

Circ Arrhythm Electrophysiol
Ananthan K, Chivers S, Regan W, de Marvao A, Vigneswaran T, Rosenthal E, Zidere V, Homfray T, Williamson C, Simpson JM, Bastiaenen R, Whitaker J.   +11 more
europepmc   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, Volume 104, Issue 6, Page 539-555, June 2026.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

High-throughput screening identifies a trafficking corrector for long QT syndrome-associated KCNQ1 variants. [PDF]

JCI Insight
Moster KRC, Vanoye CG, Chang-Gonzalez AC, Romaine IM, Stefanski KM, Wilkinson MC, Bauer JA, Hasaka TP, Days EL, Desai RR, Butcher KR, Sulikowski GA, Waterson AG, Meiler J, Ledwitch KV, George AL, Sanders CR.   +16 more
europepmc   +1 more source

The Effect of Efavirenz and Rufinamide on the Pharmacokinetics and Safety of Quizartinib: Two Phase 1 Studies in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Quizartinib is an oral, potent, selective FMS‐like tyrosine kinase 3 (FLT3) inhibitor, approved for the treatment of FLT3‐internal tandem duplication (ITD)–positive acute myeloid leukemia (AML) and under investigation in patients with newly diagnosed FLT3‐ITD–negative AML.
YoungJun Yoo, Hamim Zahir, Shinichi Inaba, Kyoin Koo, Tushar Garimella, Malaz Abutarif, Ming Zheng, Emi Kamiyama, Yuan Xu   +8 more
wiley   +1 more source

Case report: CMR work-up for a case of long QT syndrome, dilated left ventricle, and hypertension-when incidental findings unmasked the fundamental issue. [PDF]

Eur Heart J Case Rep
Aye N, Velegraki E, Mohiaddin RH.
europepmc   +1 more source

Thorough QT/QTc Clinical Study to Evaluate the Effect of Remdesivir on Cardiac Repolarization in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT QT interval prolongation associated with drug administration is an important consideration in drug development. Patients with COVID‐19 are at increased risk for cardiac complications, and QT interval prolongation correlates with higher mortality.
Chi‐Chi Peng, Ran Duan, Mazin Abdelghany, Santosh Davies, Deqing Xiao, Anna Kwan, Ana Ruiz‐Garcia   +6 more
wiley   +1 more source