Results 131 to 140 of about 4,323,638 (342)

Long-term dynamics of adaptive evolution in a globally important coccolithophore to ocean acidification

, 2015
Recent evolution experiments have revealed that marine phytoplankton may adapt to global change, for example to ocean warming or acidification. Long-term adaptation to novel environments is a dynamic process and phenotypic change can take place thousands
Thorsten B H Reusch (7137947), Schlüter, Lothar, Joachim P Gröger (7137944), Kai T Lohbeck (7137938), Lothar Schlüter (7137932), Ulf Riebesell (6964790), Gröger, Joachim P, Riebesell, Ulf, Lohbeck, Kai T, Gutowska, Magdalena A, Reusch, Thorsten B H, Magdalena A Gutowska (7137941)   +11 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Long-term telecommunication forecasting

, 2006
The key word for the thesis is long-term demand forecasting which have been applied on telecommunications and especially on broadband accesses and traffic.
Stordahl, Kjell
core  

Short- and long-term variability of the Antarctic and Greenland ice sheets

Nature Reviews Earth & Environment
The variability of the Antarctic and Greenland ice sheets occurs on various timescales and is important for projections of sea level rise; however, there are substantial uncertainties concerning future ice-sheet mass changes.
E. Hanna, Dániel Topál, J. Box, S. Buzzard, Frazer D. W. Christie, C. Hvidberg, Mathieu Morlighem, L. De Santis, A. Silvano, F. Colleoni, I. Sasgen, A. Banwell, M. R. van den Broeke, R. DeConto, J. De Rydt, H. Goelzer, Alexandra Gossart, G. Gudmundsson, Katrin Lindbäck, B. Miles, R. Mottram, F. Pattyn, R. Reese, E. Rignot, Aakriti Srivastava, Sainan Sun, J. Toller, P. A. Tuckett, Lizz Ultee   +28 more
semanticscholar   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The Non-Linear Evolution of High Frequency Short Term Interest Rates [PDF]

In this paper new results are documented regarding the short term evolution of global short term interest rates. Much work has been carried out concerning the evolution of interest rates over long time scales, on the order on one month or greater ...
David Edelman, Peter Cripwell
core  

A New Long Term Evolution LTE 3GPP Transceiver Based OFDM Multiwavelet Signals

Journal of Engineering and Sustainable Development, 2014
In this paper, an overview of the Long Term Evolution (LTE) is presented. LTE is the development of the Universal Mobile Telecommunications System (UMTS). It allows mobile users to access the Internet through their devices (mobile telephones, laptops…)
Mohammed Aboud Kadhim
doaj