Results 91 to 100 of about 957,094 (279)

Long Working Hours and Risk of Venous Thromboembolism

Epidemiology, 2018
Supplemental Digital Content is available in the text.
Kivimäki, Mika, Nyberg, Solja T., Batty, G. David, Madsen, Ida E. H., Tabák, Adam G.   +4 more
openaire   +3 more sources

Impact of long working hours on insomnia, anxiety, and depression symptoms among employees of eight manufacturing enterprises in Shenzhen

环境与职业医学
BackgroundLong working hours are a risk factor for occupational health, particularly in labor-intensive sectors such as manufacturing. Prolonged working hours may have adverse effects on the sleep and mental health of employees.ObjectiveTo investigate ...
Yingping XIANG, Juntao HE, Zihuang XIE, Wei ZHOU, Yeen HUANG   +4 more
doaj   +1 more source

Long working hours and health status among employees in Europe: between-country differences

Scandinavian Journal of Work, Environment & Health, 2013
OBJECTIVES: This study aimed to (i) identify family responsibilities associated with moderately long working hours (41–60 hours a week); (ii) examine the relationship between moderately long working hours and three health outcomes; and (iii) analyze ...
Lucía Artazcoz, Imma Cortès, Vicenta Escribà-Agüir, Xavier Bartoll, Helena Basart, Carme Borrell   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The effect of exposure to long working hours on alcohol consumption, risky drinking and alcohol use disorder: A systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-related burden of disease and injury

Environment International, 2020
Highlights • We analysed estimates of effect of long working hours on alcohol use and disorders.• Overall body of evidence was of low certainty.• Exposure to long working hours potentially increased alcohol consumption.• The effect of long working hours ...
D. Pachito, F. Pega, J. Bakusic, Emma Boonen, E. Clays, A. Descatha, E. Delvaux, D. De Bacquer, K. Koskenvuo, Hannes Kröger, Marie-Claire Lambrechts, C. Latorraca, Jian Li, A. L. Cabrera Martimbianco, R. Riera, R. Rugulies, Grace Sembajwe, J. Siegrist, L. Sillanmäki, Markku Sumanen, S. Suominen, Y. Ujita, G. Vandersmissen, L. Godderis   +23 more
semanticscholar   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of exposure to long working hours and of the effect of exposure to long working hours on depression

Environment International, 2019
Background: The World Health Organization (WHO) and the International Labour Organization (ILO) are developing a joint methodology for estimating the national and global work-related burden of disease and injury (WHO/ILO joint methodology), with ...
Reiner Rugulies, Emiko Ando, Jose Luis Ayuso-Mateos, Michela Bonafede, Maria Cabello, Cristina Di Tecco, Nico Dragano, Quentin Durand-Moreau, Hisashi Eguchi, Junling Gao, Anne H. Garde, Sergio Iavicoli, Ivan D. Ivanov, Nancy Leppink, Ida E.H. Madsen, Frank Pega, Annette M. Prüss-Üstün, Bruna M. Rondinone, Kathrine Sørensen, Kanami Tsuno, Yuka Ujita, Amy Zadow   +21 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Sleep Duration Modifies the Association of Overtime Work With Risk of Developing Type 2 Diabetes: Japan Epidemiology Collaboration on Occupational Health Study

Journal of Epidemiology, 2018
Background: Evidence linking working hours and the risk of type 2 diabetes mellitus (T2DM) is limited and inconsistent in Asian populations. No study has addressed the combined association of long working hours and sleep deprivation on T2DM risk.
Keisuke Kuwahara, Teppei Imai, Toshiaki Miyamoto, Takeshi Kochi, Masafumi Eguchi, Akiko Nishihara, Tohru Nakagawa, Shuichiro Yamamoto, Toru Honda, Isamu Kabe, Tetsuya Mizoue, Seitaro Dohi   +11 more
doaj   +1 more source