Results 111 to 120 of about 957,094 (279)

The effect of exposure to long working hours on stroke

Safety and Health at Work, 2022
Grace Sembajwe, Alexis Descatha, Sergio Iavicoli   +2 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long Hours’ Effects on Work-Life Balance and Satisfaction

BioMed Research International, 2019
Purpose. In this study, we examined whether the associations between working hours, job satisfaction, and work-life balance are mediated by occupational stress. In addition, we tested whether perceived time control helps moderate the effects of working hours and occupational stress. Methodology.
Ya-Yuan Hsu, Chyi-Huey Bai, Chien-Ming Yang, Ya-Chuan Huang, Tzu-Ting Lin, Chih-Hung Lin   +5 more
openaire   +3 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

The Effects of Workplace Rest Breaks on Health Problems Related to Long Working Hours and Shift Work among Male Apartment Janitors in Korea

Safety and Health at Work, 2019
Background: Rest breaks at work are reported to reduce fatigue and job stress. Apartment janitors in Korea who perform night shift work and work long hours can be exposed to various health problems (HPs). However, few studies have evaluated relationships
Sungjin Park, June-Hee Lee, Wanhyung Lee
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

BRIEF CONSIDERATIONS ON THE RIGHTS AND WORKING CONDITIONS OF EMPLOYEES IN THE TEXTILE AND CLOTHING INDUSTRY GLOBALLY AND IN ROMANIA [PDF]

Annals of the University of Oradea: Fascicle of Textiles, Leatherwork, 2017
It is well known that the textile and clothing industry plays an extremely important role in the global context, being one of the most powerful industries, which is capable of generating a turnover of billions of EUR.
DOCIU Maria-Ariana
doaj  

Long working hours and depressive symptoms: systematic review and meta-analysis of published studies and unpublished individual participant data.

Scandinavian Journal of Work, Environment and Health, 2018
Objectives This systematic review and meta-analysis combined published study-level data and unpublished individual-participant data with the aim of quantifying the relation between long working hours and the onset of depressive symptoms.
M. Virtanen, M. Jokela, I. Madsen, L. Hanson, T. Lallukka, S. Nyberg, L. Alfredsson, G. Batty, J. Bjorner, M. Borritz, H. Burr, N. Dragano, R. Erbel, J. Ferrie, K. Heikkilä, A. Knutsson, M. Koskenvuo, E. Lahelma, M. Nielsen, T. Oksanen, J. Pejtersen, J. Pentti, O. Rahkonen, R. Rugulies, P. Salo, J. Schupp, M. Shipley, J. Siegrist, A. Singh‐Manoux, Sakari B. Suominen, Sakari B. Suominen, T. Theorell, J. Vahtera, G. Wagner, Jian Li Wang, V. Yiengprugsawan, H. Westerlund, M. Kivimäki   +37 more
semanticscholar   +1 more source