Results 11 to 20 of about 371,915 (351)
The Gut Microbiome, Aging, and Longevity: A Systematic Review
Nutrients, 2020 Aging is determined by complex interactions among genetic and environmental factors. Increasing evidence suggests that the gut microbiome lies at the core of many age-associated changes, including immune system dysregulation and susceptibility to ...
V. D. Badal +6 more
semanticscholar +1 more source
Longevity leap: mind the healthspan gap
npj Regenerative Medicine, 2021 Life expectancy has increased by three decades since the mid-twentieth century. Parallel healthspan expansion has however not followed, largely impeded by the pandemic of chronic diseases afflicting a growing older population.
Armin Garmany, S. Yamada, A. Terzic
semanticscholar +1 more source
Importance of circadian timing for aging and longevity
Nature Communications, 2021 Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR can be achieved by controlling how much and/or when food is provided, as well as by adjusting nutritional composition.
V. Acosta-Rodríguez +3 more
semanticscholar +1 more source
DNA methylation predicts age and provides insight into exceptional longevity of bats
Nature Communications, 2021 Exceptionally long-lived species, including many bats, rarely show overt signs of aging, making it difficult to determine why species differ in lifespan.
G. Wilkinson +35 more
semanticscholar +1 more source
Genes & Development, 1999 The SIR genes are determinants of life span in yeast mother cells. Here we show that life span regulation by the Sir proteins is independent of their role in nonhomologous end joining.
M. Kaeberlein, M. McVey, L. Guarente
semanticscholar +1 more source
Oral health for achieving longevity
Geriatrics & Gerontology International, 2020 Oral frailty is defined as a decrease in oral function accompanied by a decrease in mental and physical functions. Studies showing that people with oral frailty are at high risk of physical frailty, sarcopenia, severe conditions requiring nursing care ...
Yutaka Watanabe +5 more
semanticscholar +1 more source
Applied Sciences, 2020 Plants and their corresponding botanical preparations have been used for centuries due to their remarkable potential in both the treatment and prevention of oxidative stress-related disorders. Aging and aging-related diseases, like cardiovascular disease,
B. Salehi +23 more
semanticscholar +1 more source
A meta-analysis of genome-wide association studies identifies multiple longevity genes
Nature Communications, 2019 Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age ...
J. Deelen +83 more
semanticscholar +1 more source
BMC Microbiology, 2019 Treatment with the α-glucosidase inhibitor acarbose increases median lifespan by approximately 20% in male mice and 5% in females. This longevity extension differs from dietary restriction based on a number of features, including the relatively small ...
Byron J. Smith +5 more
semanticscholar +1 more source
Animals, 2020 Simple Summary The ability of farms to produce milk sustainably is closely related to dairy cow longevity, i.e., the length of productive life. However, longevity is a very complex feature that depends on all the aspects of the lifespan of a cow and ...
G. Dallago +6 more
semanticscholar +1 more source