Results 21 to 30 of about 767,416 (302)

Whole Genome Analysis of the Red-Crowned Crane Provides Insight into Avian Longevity [PDF]

, 2020
The red-crowned crane (Grus japonensis) is an endangered, large-bodied crane native to East Asia. It is a traditional symbol of longevity and its long lifespan has been confirmed both in captivity and in the wild.
Bhak, Jong, Blazyte, Asta, Cho, Yun Sung, Choi, Jae-Pil, Chung, Oksung, Edwards, Jeremy S., Jeon, Sungwon, Jho, Sungwoong, Jun, JeHoon, Kim, Hak-Min, Kim, Jungeun, Lee, HyeJin, Lim, Jeongheui, Paek, Woon Kee, Weber, Jessica A.   +14 more
core   +1 more source

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

Changes in insulin, adiponectin and lipid concentrations with age are associated with frailty and reduced quality of life in dogs

Scientific Reports
Declining metabolic function with aging is a conserved phenotype across many species. While aging-associated changes in metabolic status have been investigated rigorously in humans, less is known about metabolic aging in dogs.
Brennen McKenzie, Matthew Peloquin, Jessica L. Graves, Frances Chen, Ashley Tovar, Tennery A. Carttar, Katya Tucker, Kenny Vo, Michelle Nelson, Kaitlyn M. Super, Jessica Austriaco, Sunny Y. Weber, Alexander Naka, Erin E. McCandless, Karen Greenwood, Dina Juarez-Salinas, Celine-Lea Halioua-Haubold, Ellen R. Ratcliff   +17 more
doaj   +1 more source

Assessing Cognitive Functioning in Children With Brain Tumors: Interaction of Neighborhood Social Determinants of Health and Neurological Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background This study investigated how neighborhood‐level social determinants of health (SDOH), including redlining and neurological risk, interact to influence cognitive outcomes in children treated for brain tumors (CTBT). Methods A retrospective chart review of 161 CTBT aged 5–17 was conducted.
Alannah R. Srsich, Manali Zope, Peter M. Fantozzi, Cassie N. Kline, Iris Paltin, Matthew C. Hocking   +5 more
wiley   +1 more source

Translational immune and metabolic markers of aging in dogs

Scientific Reports
Dogs serve as a promising aging model due to their genetic diversity, condensed lifespan, and shared living environment with humans. Alterations in the immune and metabolic parameters are hallmarks of aging in humans, but few studies have investigated ...
James E. McMahon, Jessica L. Graves, Ashley P. Tovar, Matthew Peloquin, Karen Greenwood, Frances L. Chen, Michelle Nelson, Erin E. McCandless, Celine-Lea Halioua-Haubold, Dina Juarez-Salinas   +9 more
doaj   +1 more source

Linfield Longevity [PDF]

, 2017
Shane Kimura ’78 celebrates his 40th and final season as volleyball head ...
Linfield Magazine Staff
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A novel benchmark for COVID-19 pandemic testing effectiveness enables the accurate prediction of new Intensive Care Unit admissions

Scientific Reports, 2021
The positivity rate of testing is currently used both as a benchmark of testing adequacy and for assessing the evolution of the COVID-19 pandemic. However, since the former is a prerequisite for the latter, its interpretation is often conflicting.
Dimitris Nikoloudis, Dimitrios Kountouras, Asimina Hiona   +2 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source