Results 21 to 30 of about 149,362 (257)

The Longevity of Sirtuins

Cell Reports, 2012
Controversy has recently arisen over the role of sirtuins in metazoan aging. In this issue of Cell Reports, Banerjee et al. demonstrate that Drosophila Sir2 is necessary for life span extension in response to dietary restriction and that its overexpression in the fat body increases the life span.
David Sinclair, Eric Verdin
openaire   +3 more sources

Longevity in Hungarian simmental beef purposed cattle

, 2022
The main objectives of this work were to study and analyze the longevity of the Hungarian Simmental beef purposed breed cattle. Secondly, evaluate the size of the herd, age at first calving, year, month, and season of first calving, as well as the ...
Baccouri, Wissem
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Saturated fatty acid concentrations are predictive of insulin sensitivity and beta cell compensation in dogs

Scientific Reports
Chronic feeding of a high fat diet (HFD) in preclinical species induces broad metabolic dysfunction characterized by body weight gain, hyperinsulinemia, dyslipidemia and impaired insulin sensitivity.
Matthew Peloquin, Ashley Tovar, Jessica L. Graves, Darko Stefanovski, Katya Tucker, Entonio Marietti, Karen Greenwood, Celine-Lea Halioua-Haubold, Dina Juarez-Salinas   +8 more
doaj   +1 more source

Beyond longevity: healthy longevity [PDF]

The Lancet Healthy Longevity, 2021
Alain, Putot, Sophie, Putot, Arthur, Hacquin, Patrick, Manckoundia   +3 more
openaire   +2 more sources

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Telomeres and longevity

Aging, 2012
While the basic elements of telomere biology are very similar across many taxa [1], there is diversity among species, and among tissues, in telomere dynamics. Not surprisingly, given that species differ in many other relevant aspects of their biology, including the pattern of activity of the telomere-restoring enzyme telomerase simple comparisons of ...
openaire   +2 more sources

A memory of longevity

eLife, 2020
Worms with increased levels of the epigenetic mark H3K9me2 have a longer lifespan that can be passed down to future generations.
Felicity Emerson, Cheng-Lin Li, Siu Sylvia Lee   +2 more
openaire   +3 more sources

Evolutionary conservation of regulated longevity assurance mechanisms [PDF]

, 2007
Background: To what extent are the determinants of aging in animal species universal? Insulin/ insulin-like growth factor ( IGF)-1 signaling ( IIS) is an evolutionarily conserved ( public) regulator of longevity; yet it remains unclear whether the genes ...
Linda Partridge, Piper, Matthew D., David Gems, Schuster, E, Piper, MD, Gems, D, McElwee, J.J., Thomas, J.H., Partridge, L., Joshua J McElwee, Withers, D.J., McElwee, JJ, Patel, DS, Dhaval S Patel, Thornton, J.M., Blanc, E, Matthew D Piper, McElwee, J.J, Patel, Dhaval S., Withers, Dominic J., Schuster, E., Dominic J Withers, Janet M Thornton, Selman, C, Withers, DJ, Thorton, Janet M., Selman, C., Eugene Schuster, Selman, Colin, Partridge, Linda, Piper, M.D., Blanc, Eric, Thomas, JH, Eric Blanc, Patel, D, McElwee, Joshua J., Gems, D., James H Thomas, Partridge, L, Blanc, E., Thornton, JM, Gems, David, Schuster, Eugene, Thomas, J H, Colin Selman, Piper, M D, Patel, D.S., Thomas, James H.   +47 more
core   +1 more source