Results 11 to 20 of about 149,362 (257)

Familial longevity is marked by lower diurnal salivary cortisol levels: the leiden longevity study [PDF]

, 2012
Background Reported findings are inconsistent whether hypothalamic-pituitary-adrenal (HPA) signaling becomes hyperactive with increasing age, resulting in increasing levels of cortisol.
Westendorp, Rudi G J, Oei Nicole Y. L., Maier, Andrea B., Jansen, Steffy W M, Maier, A.B., de Craen, Anton J M, Akintola, Abimbola A., Pijl Hanno, Noordam, Raymond, Slagboom, P. Eline, Hanno Pijl, Diana van Heemst, Raymond Noordam, Jansen, SWM, Westendorp, RGJ, van der Grond Jeroen, Westendorp Rudi G. J., van Heemst, Diana, P Eline Slagboom, Noordam, R., Steffy W M Jansen, Heemst, D. van, Leiden Longevity Study group, Craen, A.J.M. de, van der Grond, J, Oei, Nicole YL, Jeroen van der Grond, van Heemst Diana, Anton J M de Craen, de Craen Anton J. M., Jansen, S.W.M., van Heemst, D, Noordam, R, de Craen, AJM, Akintola Abimbola A., Grond, J. van der, Pijl, Hanno, Oei, N.Y.L., Maier, Andrea B.; id_orcid, Rudi G J Westendorp, Maier, AB, Maier Andrea B., Pijl, H., Leiden Longevity Study Grp, Slagboom, PE, Noordam Raymond, Nicole Y L Oei, Jansen, Steffy, Slagboom, P.E., de Craen, Anton JM, Oei, Nicole Y L, Andrea B Maier, Jansen Steffy W. M., Oei, NYL, Westendorp, R.G.J., van der Grond, Jeroen, Akintola, Abimbola A, Abimbola A Akintola, Slagboom P. Eline, Akintola, A.A., Akintola, AA, Maier, Andrea B, Westerndorp, Rudi GJ, Pijl, H   +63 more
core   +1 more source

Should we Subsidize Longevity? [PDF]

This paper studies the design of the optimal non linear taxation in an economy where longevity varies across agents, and depends on three factors: longevity genes, health investment and farsightedness.
Marie-Louise Leroux, Pierre Pestieau, Grégory Ponthiere   +2 more
core   +4 more sources

Efficient versus inefficient hedging strategies in the presence of financial and longevity (value at) risk [PDF]

, 2013
This paper provides a closed-form Value-at-Risk (VaR) for the net exposure of an annuity provider, taking into account both mortality and interest-rate risk, on both assets and liabilities.
Regis, Luca, Luciano, Elisa
core   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A novel benchmark for COVID-19 pandemic testing effectiveness enables the accurate prediction of new Intensive Care Unit admissions

Scientific Reports, 2021
The positivity rate of testing is currently used both as a benchmark of testing adequacy and for assessing the evolution of the COVID-19 pandemic. However, since the former is a prerequisite for the latter, its interpretation is often conflicting.
Dimitris Nikoloudis, Dimitrios Kountouras, Asimina Hiona   +2 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

ALCOHOL AND LONGEVITY. [PDF]

The Lancet, 1891
n ...
Ridge, J. J., Sers, ClementH
  +4 more sources