Results 21 to 30 of about 228,146 (310)
eLife, 2020 Worms with increased levels of the epigenetic mark H3K9me2 have a longer lifespan that can be passed down to future generations.
Felicity Emerson +2 more
openaire +4 more sources
Adapting Blood DNA Methylation Aging Clocks for Use in Saliva Samples With Cell-type Deconvolution
Frontiers in Aging, 2021 DeepMAge is a deep-learning DNA methylation aging clock that measures the organismal pace of aging with the information from human epigenetic profiles.
Fedor Galkin +5 more
doaj +1 more source
The evolution of longevity [PDF]
Current Biology, 2002 According to the evolutionary theory of ageing, genes will not evolve for the purpose of promoting ageing. Moreover, the mutation–accumulation theory predicts that mutations in different genes will cause ageing in different evolutionary lineages. However, as discussed, empirical evidence does not generally support mutation–accumulation as a mechanism ...
David Gems, Linda Partridge
openaire +3 more sources
Communications Biology, 2022 TrxR2 overexpression in mice enhances metabolism and prevents high-fat diet induced metabolic deficits in mice through alteration in function of several enzymes in the tricarboxylic acid cycle and complexes of the electron transport chain.
E. Sandra Chocron +4 more
doaj +1 more source
Ironing out exercise on immuno-oncological outcomes
Journal for ImmunoTherapy of Cancer, 2022 Despite accumulating evidence that supports the beneficial effects of physical exercise in inhibiting cancer progression, whether exercise modulates its effects through systemic and cellular changes in iron metabolism and immune-tumor crosstalk is ...
Elaine Hsuen Lim +4 more
doaj +1 more source
Cell Reports, 2012 Controversy has recently arisen over the role of sirtuins in metazoan aging. In this issue of Cell Reports, Banerjee et al. demonstrate that Drosophila Sir2 is necessary for life span extension in response to dietary restriction and that its overexpression in the fat body increases the life span.
David A. Sinclair, Eric Verdin
openaire +4 more sources
Scientific Reports, 2023 Cranial cruciate ligament (CCL) rupture is one of the most commonly diagnosed orthopedic conditions of pet dogs, making estimated lifetime cruciate ligament survival an attractive endpoint for studies attempting to define clinical and genetic correlates ...
David J. Waters +6 more
doaj +1 more source
Utilization of defined microbial communities enables effective evaluation of meta-genomic assemblies
BMC Genomics, 2017 Background Metagenomics is the study of the microbial genomes isolated from communities found on our bodies or in our environment. By correctly determining the relation between human health and the human associated microbial communities, novel mechanisms
William W. Greenwald +7 more
doaj +1 more source
Beyond longevity: healthy longevity [PDF]
The Lancet Healthy Longevity, 2021 Sophie Putot +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source