Results 41 to 50 of about 730,309 (342)

A set of common buccal CpGs that predict epigenetic age and associate with lifespan-regulating genes

open access: yesiScience, 2022
Summary: Epigenetic aging clocks are computational models that use DNA methylation sites to predict age. Since cheek swabs are non-invasive and painless, collecting DNA from buccal tissue is highly desirable.
Adiv A. Johnson   +3 more
doaj  

Semi‐automated hippocampal avoidance whole‐brain radiotherapy planning

open access: yesJournal of Applied Clinical Medical Physics, Volume 26, Issue 7, July 2025.
Abstract Background Hippocampal avoidance whole‐brain radiotherapy (HA‐WBRT) is designed to spare cognitive function by reducing radiation dose to the hippocampus during the treatment of brain metastases. Current manual planning methods can be time‐consuming and may vary in quality, necessitating the development of automated approaches to streamline ...
Dong Joo Rhee   +9 more
wiley   +1 more source

Self-reported adverse events associated with ∆8 -Tetrahydrocannabinol (Delta-8-THC) Use

open access: yesJournal of Cannabis Research, 2023
Background There is an expanding unregulated market for a psychotropic compound called ∆8-Tetrahydrocannabinol (delta-8-THC) that is being derived from hemp, but a summary of adverse events related to delta-8-THC has not been publicly reported.
Eric C. Leas   +6 more
doaj   +1 more source

Colony and individual life-history responses to temperature in a social insect pollinator [PDF]

open access: yes, 2015
Pollinating insects are of major ecological and commercial importance, yet they may be facing ecological disruption from a changing climate. Despite this threat, few studies have investigated the life-history responses of pollinators to experimentally ...
Bourke, Andrew F. G., Holland, Jacob G.
core   +2 more sources

A Novel CHMP2B Splicing Variant in Atypical Presentation of Familial Frontotemporal Lobar Degeneration

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra   +17 more
wiley   +1 more source

LONGEVITY OF PHYSICIANS. [PDF]

open access: yesJAMA: The Journal of the American Medical Association, 1896
All men think all men mortal, but themselves.—Young. "It is a swift current—that stream of life, on which we ride. We fall asleep, and awaking, find ourselves almost home. Our companions, too, are constantly changing; at every moment new ones come aboard, and old ones leave us, and we have scarcely time to become familiar with their faces, or to make ...
openaire   +2 more sources

Longevity and mortality in Kennel Club registered dog breeds in the UK in 2014 [PDF]

open access: yes, 2018
Background The domestic dog is one of the most diverse mammalian species, exhibiting wide variations in morphology, behaviour and morbidity across breeds.
Evans, K M   +4 more
core   +1 more source

Brain Characteristics in Patients With Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disorder by 7.0 Tesla MRI

open access: yesAnnals of Clinical and Translational Neurology, Volume 12, Issue 7, Page 1431-1441, July 2025.
ABSTRACT Background Myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) can radiographically mimic multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). The disease hallmarks cortical lesion, central vein sign (CVS) and paramagnetic rim lesions identified in MS have not yet been comprehensively investigated in ...
Lei Su   +19 more
wiley   +1 more source

Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer’s disease-like neuroinflammation and cognitive impairment

open access: yesMolecular Neurodegeneration, 2021
Background Human genetic association studies point to immune response and lipid metabolism, in addition to amyloid-beta (Aβ) and tau, as major pathways in Alzheimer’s disease (AD) etiology.
Shulan Qiu   +12 more
doaj   +1 more source

Longevity and aging [PDF]

open access: yesF1000Prime Reports, 2013
Research into the biology of aging seeks to understand the basic mechanisms of aging, with the goal of extending the period of life spent free from chronic disease and disability. Aging results from molecular processes that are modulated by genetic and environmental parameters.
openaire   +3 more sources

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