Results 41 to 50 of about 810,836 (243)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

MMP Inhibitors and Dentin Bonding: Systematic Review and Meta-Analysis

International Journal of Dentistry, 2021
Objectives. Resin-dentin bond strength decreases over time. This reduction is related to the loss of hybrid layer integrity. Collagenolytic enzymes, especially matrix metalloproteinases (MMPs), are responsible for the degradation of the collagen matrix ...
O. Kiuru, J. Sinervo, H. Vähänikkilä, V. Anttonen, L. Tjäderhane   +4 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Familial longevity is marked by lower diurnal salivary cortisol levels: the leiden longevity study [PDF]

, 2012
Background Reported findings are inconsistent whether hypothalamic-pituitary-adrenal (HPA) signaling becomes hyperactive with increasing age, resulting in increasing levels of cortisol.
Westendorp, Rudi G J, Oei Nicole Y. L., Maier, Andrea B., Jansen, Steffy W M, Maier, A.B., de Craen, Anton J M, Akintola, Abimbola A., Pijl Hanno, Noordam, Raymond, Slagboom, P. Eline, Hanno Pijl, Diana van Heemst, Raymond Noordam, Jansen, SWM, Westendorp, RGJ, van der Grond Jeroen, Westendorp Rudi G. J., van Heemst, Diana, P Eline Slagboom, Noordam, R., Steffy W M Jansen, Heemst, D. van, Leiden Longevity Study group, Craen, A.J.M. de, van der Grond, J, Oei, Nicole YL, Jeroen van der Grond, van Heemst Diana, Anton J M de Craen, de Craen Anton J. M., Jansen, S.W.M., van Heemst, D, Noordam, R, de Craen, AJM, Akintola Abimbola A., Grond, J. van der, Pijl, Hanno, Oei, N.Y.L., Maier, Andrea B.; id_orcid, Rudi G J Westendorp, Maier, AB, Maier Andrea B., Pijl, H., Leiden Longevity Study Grp, Slagboom, PE, Noordam Raymond, Nicole Y L Oei, Jansen, Steffy, Slagboom, P.E., de Craen, Anton JM, Oei, Nicole Y L, Andrea B Maier, Jansen Steffy W. M., Oei, NYL, Westendorp, R.G.J., van der Grond, Jeroen, Akintola, Abimbola A, Abimbola A Akintola, Slagboom P. Eline, Akintola, A.A., Akintola, AA, Maier, Andrea B, Westerndorp, Rudi GJ, Pijl, H   +63 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Influence of Immediate Dentin Sealing on Bond Strength of Resin-Based CAD/CAM Restoratives to Dentin: A Systematic Review of In Vitro Studies

Biomimetics
Immediate dentin sealing (IDS) is a method of improving the bond strength of indirect dental restorative materials to dentin and belongs to the biomimetic protocols of contemporary dentistry.
Iliana Antoniou, Petros Mourouzis, Dimitrios Dionysopoulos, Panagiotis Pandoleon, Kosmas Tolidis   +4 more
doaj   +1 more source

Longevity gene responsible for robust blue organic materials employing thermally activated delayed fluorescence

Nature Communications, 2023
The 3rd-Gen OLED materials employing thermally-activated delayed fluorescence (TADF) combine advantages of first two for high-efficiency and low-cost devices. Though urgently needed, blue TADF emitters have not met stability requirement for applications.
Qing-Yu Meng, Rui Wang, Yi-Lei Wang, Xing-Wei Guo, Yu-Qi Liu, Xue-Liang Wen, Cheng-Yu Yao, Juan Qiao   +7 more
doaj   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Current Status and Challenges in Data Collection for Aerospace Coatings Deposited by Plasma Spraying

Advanced Engineering Materials, EarlyView.
An innovative approach has been integrated into the GRENAT project to optimize plasma spraying and coating performance. Raw materials are accelerated and melted in the plasma generated by torches, creating coatings. Monitoring sensors collect process data which are combined with ex situ characterization data.
Lila Randriamananjara, Vincent Rat, Quentin Dubreuil, Patrice Valorge, Simon Goutier, Alain Denoirjean, Olivier Messe, Céline Ruelle, Jean‐Philippe Poli   +8 more
wiley   +1 more source

Electrospun Wood‐Derived Biopolymers as Electrodes in Electrochemical Energy Storage Technologies

Advanced Functional Materials, EarlyView.
Electrospinning transforms wood‐derived cellulose and lignin into architecturally defined, binder‐free carbon electrodes with tuneable porosity and functionality. This review shows how fibre design enables decoupled charge and mass transport, enhancing performance across battery systems, while identifying key challenges in spinnability, scalability ...
Michael W. Thielke, Hattie R. Chisnall, Jesus Vazquez Chavez, Ana B. Jorge Sobrido   +3 more
wiley   +1 more source