Results 91 to 100 of about 1,229,920 (265)

Direct Visualization of Longitudinal Data

, 2010
This session examines best practice standards associated with managing and archiving longitudinal data. The data structure of longitudinal studies is more complex than for one-dimensional study designs and therefore new issues typically arise with the process of data management, archiving and analysis.
openaire   +3 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Artificial Intelligence-Based Models for Predicting Disease Course Risk Using Patient Data

Computers
Nowadays, longitudinal data are common—typically high-dimensional, large, complex, and collected using various methods, with repeated outcomes. For example, the growing elderly population experiences health deterioration, including limitations in ...
Rafiqul Chowdhury, Wasimul Bari, M. Tariqul Hasan, Ziaul Hossain, Minhajur Rahman   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Studying school communities as multiplex dynamic networks: The “RECENS Wired into Each Other” Dataset, 2010–2013

Connections
This article provides an overview of the “Research Center for Educational and Network Studies (RECENS) Wired into each other” longitudinal social network study conducted in 44 secondary-school classrooms in Hungary between 2010 and 2013.
Vörös András, Boda Zsófia, Csaba Zoltán László, Kisfalusi Dorottya, Radó Márta, Varga Kinga, Takács Károly   +6 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Heterogeneous trajectories of executive function in clinical Alzheimer's disease: Results from the 3C study

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
BACKGROUND Alzheimer's disease (AD) shows considerable heterogeneity in cognitive decline. Executive function (EF), a core cognitive domain, may contribute to this heterogeneity and modulate AD progression. METHODS We analyzed the trajectories of four EF‐
Hélène Amieva, Maris Dussartre, Viviane Philipps, Anaïs Rouanet, Carole Dufouil, Hélène Jacqmin‐Gadda, Jean‐François Dartigues, Karine Pérès, Cécilia Samieri, Gwenaëlle Catheline, Catherine Helmer, Cécile Proust‐Lima   +11 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source