Results 31 to 40 of about 614,697 (267)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Study on the influence of airflow disturbance on spray atomization [PDF]
E3S Web of ConferencesThe droplet distribution characteristics are one of the key factors that determine the dust suppression effect of spray system. In order to study the droplet distribution characteristics under different working conditions, the influence mechanism of wind
Mo Jinming
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Estimation of longitudinal bunch characteristics in the LHC using Schottky-based diagnostics
Physical Review Accelerators and Beams, 2020 The Large Hadron Collider (LHC) Schottky monitors have been designed to measure various parameters of relevance to beam quality, namely tune, momentum spread, and chromaticity.
Kacper Lasocha, Diogo Alves
doaj +1 more source
Photonics, 2023 The paper shows that it is possible to obtain reliable information on the dependence of the radial distribution of longitudinal birefringence in glass cylindrical elements with a radial distribution of refractive index (GRIN lenses) on the basis of ...
Andrey A. Lipovskii +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Frontiers in Big Data, 2022 Joint models of longitudinal and time-to-event data have received a lot of attention in epidemiological and clinical research under a linear mixed-effects model with the normal assumption for a single longitudinal outcome and Cox proportional hazards ...
Yangxin Huang +3 more
doaj +1 more source
Bag of little bootstraps for massive and distributed longitudinal data
Statistical Analysis and Data Mining: The ASA Data Science Journal, 2021 AbstractLinear mixed models are widely used for analyzing longitudinal datasets, and the inference for variance component parameters relies on the bootstrap method. However, health systems and technology companies routinely generate massive longitudinal datasets that make the traditional bootstrap method infeasible. To solve this problem, we extend the
Xinkai Zhou, Jin J. Zhou, Hua Zhou 0001
openaire +4 more sources
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source