Results 111 to 120 of about 1,107,400 (287)

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Continuous Molecular Monitoring Using Electrochemical Aptamer‐Based Sensors: Remaining Challenges for Long‐Term In Vivo Deployment

Advanced Science, EarlyView.
Continuous molecular monitoring using electrochemical aptamer‐based sensors enables real‐time tracking of dynamic biomarkers with transformative potential for precision medicine. Achieving clinically relevant month‐long stability remains a central challenge due to multiple degradation pathways.
Shibo Liu, Xiangling Li, Wei Ouyang
wiley   +1 more source

Experimental investigation of the impacts of mechanical defects and pollution patterns on leakage current harmonics in composite insulators

Energy Reports
Composite insulators are widely used in power transmission and distribution systems due to their high pollution resistance and superior insulating performance.
Mehrdad Ghorbani Pashakolaei, Mostafa Jazaeri, Mohsen Niasati, SeyyedMeysam Seyyedbarzegar   +3 more
doaj   +1 more source

Enhancing Quasi‐Two‐Dimensional Electronic Structure in Bi2O2Se via Chlorine Substitution

Advanced Science, EarlyView.
We demonstrate chlorine substitution as an effective strategy to transform Bi2O2Se into an exfoliatable van der Waals superlattice. Key electronic band feature, including indirect bandgap, effective mass is well preserved, while the 2D character of the system is sufficiently enhanced.
Yong‐Zhen Jiang, Qi‐Xun Wen, Xiang Xu, Su‐Tao Sun, Feng‐Fan Ren, Zi‐Xuan Zhou, Xing‐Yuan You, Yu‐Cheng Kan, Zheng Zhang, Jie‐Yi Liu, Yu‐Zhou Zhao, Zheng‐Tai Liu, Mao Ye, Shu‐Hua Yao, Jian Zhou, Yan‐Bin Chen, Zhong‐Kai Liu, Yu‐Lin Chen, Yang‐Yang Lv, Cheng Chen   +19 more
wiley   +1 more source

Amyloid fibrils of the myelin basic protein are an integral component of myelin in the vertebrate brain

Scientific Reports
The myelin basic protein (MBP) is the most abundant intracellular protein of the myelin, which forms the electrically insulating sheath of axons of many actively functioning neurons. This protein binds the opposite membranes of the flattened processes of
Evgeniy I. Sysoev, Aleksandr A. Shenfeld, Tatyana A. Belashova, Anna A. Valina, Sergey P. Zadorsky, Alexey P. Galkin   +5 more
doaj   +1 more source

Experimental Study on the Influence of High-Pressure Water Mist on the Ceiling Temperature of a Longitudinally Ventilated Tunnel

Fire
In this study, a tunnel model with a length of 20 m, a width of 5 m, and a height of 5 m was used, and an experimental investigation was conducted to examine the impact of high-pressure water mist on the temperature distribution along the tunnel ceiling.
Hui Zhu, Weining Du, Wenfeng Li
doaj   +1 more source

Vine‐Inspired Soft Robotics: Materials, Actuations, and Emerging Applications

Advanced Science, EarlyView.
Vine‐inspired robots grow from the tip, enabling navigation through confined spaces with minimal disturbance. This Review summarizes material and actuation strategies for vine‐inspired growth, key functions including steering, retraction, attachment, branching, and variable stiffness, and emerging applications spanning medical intervention, confined ...
Jiahao Wu, Xingyun Liu, Fangzhou Wang, Huili Ren, Chaojun Zhang, Ziyu Ren, Zunqi Liu, Jing Li   +7 more
wiley   +1 more source

A Systematic Review of Indoor Environmental Quality in Age-Friendly Housing

Buildings
The rapid global ageing population highlights the pressing need for age-friendly housing that supports independent and healthy ageing in place. Indoor environmental quality (IEQ), encompassing thermal comfort, air quality, acoustic environment, lighting,
Peiyao Li, Nur Dalilah Dahlan, Jazmin Mohamad Jaafar, Nianyou Zhu   +3 more
doaj   +1 more source

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

Advanced Science, EarlyView.
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen, Bin He, Kuan Liu, Zhuo Ma, Bin Xu   +4 more
wiley   +1 more source

Interfacial Asymmetry and Surface Roughness Enhanced Topological‐Hall‐Like Transport in SRO/BTO/SRO Trilayers

Advanced Science, EarlyView.
Trilayer oxide architecture introduces interfacial asymmetry and surface roughness in SRO/BTO/SRO heterostructures, creating a locally modulated polar and magnetic landscape. This design enhances the topological‐Hall‐like response, achieving a broad 5–90 K stability window and a maximum ρTHE of 0.8 µΩ cm, demonstrating an effective route to amplify ...
Sagar E. Shirsath, Yunlong Sun, Xichao Zhang, Ji Zhang, Akash V. Fulari, Zizheng Song, Yee Yan Tay, Yin Yao, Zibin Chen, Sean Li, Xiaoxi Liu, Danyang Wang   +11 more
wiley   +1 more source