Results 81 to 90 of about 1,836,276 (227)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

“UPDATE: I’m pregnant!”: Inferring global downloads and reasons for using menstrual tracking apps

Digital Health
Objective The market for smartphone apps tracking menstrual cycles has expanded in recent years. These apps market themselves as empowering users to achieve their reproductive goals and maximize the chance of pregnancy. This paper presents the first open-
Francesco Rampazzo, Alyce Raybould, Pietro Rampazzo, Ross Barker, Douglas Leasure   +4 more
doaj   +1 more source

Measurement error in long-term retrospective recall surveys of earnings [PDF]

, 2007
Several recent studies in labour and population economics use retrospective surveys to substitute for the high cost and limited availability of longitudinal survey data.
Gibson, John, Kim, Bonggeun
core   +1 more source

A longitudinal study of migration propensities for mixed-ethnic unions in England and Wales [PDF]

, 2015
This research was funded by the ESRC under the Understanding Population Trends and Processes (UPTAP) programme (Award Ref: RES-163-25-0045).Most studies investigating residential segregation of ethnic minorities ignore the fact that the majority of ...
Boyle, P., Feng, Z., Raab, G.M., van Ham, M.   +3 more
core   +1 more source

Longitudinal demographic study of wild populations of African annual killifish

Scientific Reports, 2018
AbstractThe natural history of model organisms is often overlooked despite its importance to correctly interpret the outcome of laboratory studies. Ageing is particularly understudied in natural populations. To address this gap, we present lifetime demographic data from wild populations of an annual species, the turquoise killifish,Nothobranchius ...
Milan Vrtílek, Jakub Žák, Matej Polačik, Radim Blažek, Martin Reichard   +4 more
openaire   +4 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Although Coronary Mortality Has Decreased, Rates of Cardiovascular Disease Remain High: 21 Years of Follow‐Up Comparing Cohorts of Men Born in 1913 With Men Born in 1943

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundDespite a decline in mortality rates from cardiovascular disease (CVD) in the past few decades, the burden of CVD in a contemporary population remains inadequately addressed.
Michael Fu, Annika Rosengren, Erik Thunström, Zacharias Mandalenakis, Lennart Welin, Kenneth Caidahl, Aldina Pivodic, You Zhong, Constantinos Ergatoudes, David Morales, Catharina Welin, Kurt Svärdsudd, Mikael Dellborg, Per‐Olof Hansson   +13 more
doaj   +1 more source

q2-longitudinal: Longitudinal and Paired-Sample Analyses of Microbiome Data

mSystems, 2018
Studies of host-associated and environmental microbiomes often incorporate longitudinal sampling or paired samples in their experimental design.
Nicholas A. Bokulich, Matthew R. Dillon, Yilong Zhang, Jai Ram Rideout, Evan Bolyen, Huilin Li, Paul S. Albert, J. Gregory Caporaso   +7 more
doaj   +3 more sources

Longitudinal studies based on the general population – Important studies becoming rare nowadays [PDF]

Respiratory Medicine, 2019
Longitudinal studies based on the general population : Important studies becoming rare ...
Eva, Rönmark, Johann Christian, Virchow, Bo, Lundbäck   +2 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source