Results 171 to 180 of about 14,354,496 (289)

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Public involvement and co-design of longitudinal studies of sleep health alongside young people with rare genetic conditions. [PDF]

Res Involv Engagem
Clayton JP, Haddon JE, Hall J, Attwood M, Jarrold C, Berndt LCS, Saka A, van den Bree MBM, Jones MW, Sleep Detectives Lived Experience Advisory Panel.   +9 more
europepmc   +1 more source

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu, Changgeng Song, Dianwei Wu, Xiaoqian Niu, Jianmin Hao, Lijuan Liu, Xiaogang Kang, Wen Jiang   +7 more
wiley   +1 more source

Latent transition analysis for longitudinal studies of post-acute infection syndromes. [PDF]

Nat Commun
Gusinow R, Górska A, Canziani LM, Lopes-Rafegas I, Alvarez Garavito C, Tami A, Gentilotti E, Sicuri E, Laouénan C, Ghosn J, Florence AM, Lahfej N, Mazzaferri F, Del Piccolo L, Giannella M, Toschi A, Di Chiara M, Caponcello MG, Palacios-Baena ZR, Wold KI, Rossi E, Tacconelli E, Hasenauer J, ORCHESTRA study group.   +23 more
europepmc   +1 more source

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Fabio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

The growing inter-disciplinary field of longitudinal studies beginning in early life: this journal's response [PDF]

, 2013
Dezateux, Carol, Wadsworth, Michael
core   +1 more source

Six anthropometric indices and all-cause mortality in ageing populations: an observational cohort study in six longitudinal studies. [PDF]

BMC Public Health
Xu D, Yin J, Shen W, Zheng X, Xu J.
europepmc   +1 more source

Disease Course After Anti‐CD20 Discontinuation in Secondary Progressive Multiple Sclerosis—A Multicenter Long‐Term Longitudinal Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe long‐term outcomes after anti‐CD20 discontinuation in selected patients with secondary progressive multiple sclerosis (SPMS) who remained without subsequent disease‐modifying therapy (DMT). Methods We retrospectively analyzed data from four centers in Austria and Switzerland.
Ferdinand Otto, Dariia Kliushnikova, Richard Friedrich Radlberger, Sinan Yasaroglu, Tobias Moser, Andrea Harrer, Kitty Kratzer, Wolfgang Hitzl, Christiane Gradl, Martin Schmidauer, Patrick Roth, Harald Hegen, Peter Wipfler   +12 more
wiley   +1 more source

Adolescent physical activity trajectories and later non-communicable disease risk factors: A systematic review of longitudinal studies. [PDF]

Public Health Pract (Oxf)
Paramashiva PS, Sukumar S, Shettigar D, Vaishali K, Chandrasekaran B, Palaniswamy HP, Dkhar W, Pradhan A, Panakkal NC, David LR, Nagari SK, Srivastav P, Bommasamudram T, Amin R, Naga Padmaja KS, Ravichandran S, Muthu SS, Kamath K, Barnes NA.   +18 more
europepmc   +1 more source