Results 61 to 70 of about 43,291,481 (361)
The Brazilian Longitudinal Study of Aging (ELSI-Brazil): Objectives and Design
American Journal of Epidemiology, 2018 Brazil is experiencing among the world’s fastest demographic aging worldwide. This demographic transition is occurring in a context of few resources and great social inequalities.
M. Lima-Costa +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
BMC Health Services Research, 2020 Background End-of-life experience is a subject of significant policy interest. National longitudinal studies offer valuable opportunities to examine individual-level experiences.
Peter May +4 more
doaj +1 more source
HRB Open Research, 2023 Background: Reliable data on health care costs in Ireland are essential to support planning and evaluation of services. New unit costs and high-quality utilisation data offer the opportunity to estimate individual-level costs for research and policy ...
Samantha Smith +10 more
doaj +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
International Journal of Population Data Science, 2018 Background Losing independence is a concern for older people, and sadly a reality for many. In Scotland there is an ageing population and unlike the rest of the UK, a policy to provide free personal and nursing care for those in need of assistance; this ...
D. Helen Corby +4 more
doaj +1 more source
Preventive Medicine Reports, 2021 Research on whether sedentary behaviour (SB) is related to cognitive decline in older individuals is conflicting, potentially caused by methodological differences in previous studies.
Carlijn M. Maasakkers +6 more
doaj +1 more source
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
Scientific Reports, 2022 Little is known about the within-person variability of different frailty instruments, their agreement over time, and whether use of repeat assessments could improve the strength of associations with adverse health outcomes.
Dani J. Kim +6 more
doaj +1 more source