Results 71 to 80 of about 43,291,481 (361)

Overuse and underuse of cardiovascular diagnostic and therapeutic procedures for community-dwelling adults: a protocol for a systematic review [version 1; peer review: 2 approved]

HRB Open Research, 2021
Background: Potentially inappropriate care can result from overuse or underuse of treatments, tests, or procedures. Overuse is defined as the use of health services with no clear benefit to the recipient or where harms outweigh benefits and/or costs of ...
David Byrne, Dominic Quinn, Fiona Boland, Tom Fahey, Emma Wallace, Christine McGarrigle, Rose Anne Kenny   +6 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Wandering in Dementia: A Longitudinal Study

International Psychogeriatrics, 2001
This article analyzes the natural history of wandering behavior throughout the course of dementia.Prospective, 10-year, longitudinal study of wandering behavior in dementia, with autopsy follow-up.Participants with dementia, living at home with a carer.
Hope, T, Keene, J, McShane, R, Fairburn, C, Gedling, K, Jacoby, R   +5 more
openaire   +3 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Outcomes of the Health Data Research Network (HDRN) Canada and Canadian Longitudinal Study on Aging (CLSA) Partnership

International Journal of Population Data Science
Objective and Approach The Canadian Longitudinal Study on Aging (CLSA) is the largest national longitudinal cohort study, following ~50,000 adults across 10 provinces for at least 20 years. Health Data Research Network (HDRN) Canada is a distributed pan-
Anne Hayes, Sophie Hogeveen, Jodi Gatley, Andrew Costa, Lauren Griffith, Aaron Jones, Sarah Youssef, Parminder Raina, Andrea Gruneir, Carrie Anne Whyte, Carla Hovey, Marie-Chantal Ethier, Donna Curtis Maillet, Mahmoud Azimaee, Erik Youngson, Tim Choi, Lindsey Gilbert, Magda Nunes De Melo, Lindsay Stewart, Kendra Lester, Katelyn Frizzell, Robyn Kydd, Mary-Ann Standing, Charles Burchill, Dave Towns, Jean-Francois Cantin   +25 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Dementia and caregiver burden: A three‐year longitudinal study

International Journal of Geriatric Psychiatry, 2019
Dementia, with its progressive cognitive and functional decline and associated neuropsychiatric symptoms, places a large burden on caregivers. While frequently studied, longitudinal findings about the overall trajectory of burden are mixed.
Michael H. Connors, K. Seeher, A. Teixeira-Pinto, M. Woodward, D. Ames, H. Brodaty   +5 more
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Langer thuis, mythe of nieuwe maatschappelijke modus?

Tijdschrift voor Gerontologie en Geriatrie, 2015
Jaarlijks beantwoorden onderzoekers van de Longitudinal Aging Study Amsterdam (LASA) relevante en actuele beleidsvraagstukken van het Ministerie van VWS en schrijven daar een rapport over.
Noëlle Sant, Martijn Huisman, G. C. F. (Fleur) Thomése, Rian van de Schoot, Sven Turnhout, Mirella M.N. Minkman   +5 more
doaj   +1 more source