Results 41 to 50 of about 15,433 (290)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Loom weights – a general typology of finds from Poland
Przegląd Archeologiczny, 2019 This article presents a proposal for the general classification of loom weights used as elements of the warp-weighted loom, which is the oldest and longest used tool for the production of fabrics.
Joanna Słomska
doaj +1 more source
Knife and Belt: Analysis of Seima-Turbino Bronze Weapons
Вестник Кемеровского государственного университета, 2021 A bronze knife from the burial site near Rostovka village was found in a grave under the skull bones that belonged to a nine–ten-year-old child. Sopka-2/4B Krotovo necropolis has two burials, in which daggers were found under the bones of a child and a ...
Yu. I. Mikhailov
doaj +1 more source
, 2023 Textile machinery, power loom. Inscription on loom reads: DRAPER CORPORATION / HOPEDALE, MASS.https://jdc.jefferson.edu/historical_photos_ef/1060/thumbnail ...
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Early Medieval Looms in Poland in the Light of Archaeological Finds
Fasciculi Archaeologiae Historicae, 2018 The purpose of the paper is to present types of looms used in Poland in the Early Middle Ages in the light of archaeological finds. The basis for the source form parts of looms like loom weights and weaving tools. The authors present evidence discovered
Łukasz Antosik, Joanna Słomska
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Convex Loom Weights in the Akarçay Basin and its Surroundings
Anadolu AraştırmalarıThe Akarçay basin and its surrounding mountainous areas have long been vital for livestock activities and wool and textile production, both in the Bronze Ages and today.
Özdemir Koçak, Kamal Bayramov
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source