Results 51 to 60 of about 15,433 (290)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Women’s work: The dedication of loom weights in the sanctuaries of southern Italy

open access: yesPallas, 2011
Loom weights are a common find in the sanctuaries of the ancient world. These small, portable, and inexpensive objects, however, are often marginalised in scholarship as merely remnants of weaving that took place at the site, or as low status dedications.
Alexandra Sofroniew
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Hecate's Loom : no.30(1995)

open access: yes, 1995
In this issue of Hecate’s Loom, the first major articles examine the concept of being a witch and what that entails. This includes but is not limited to Ethos and Ethics, the Pagan Federation, Witches in the southwest, gatherings and a various collection

core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Med silke til Valhall. En studie av mønster og vevemetoder

open access: yesViking, 2017
With silk for Valhalla. A study of pattern and weaving methods In the Oseberg ship burial patterned silk fabrics from Central Asia were found. The collection of fabrics contained 110 small fragments woven in samitum, derived from up to 15 different ...
Åse Eriksen
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Understanding the Archaeological Record: Reconstructing a Warp-Weighted Loom

open access: yesEXARC Journal, 2018
The paper deals with a reconstruction of a warp-weighted loom based on a rare find of 36 in situ loom weights in an object interpreted as a weaving hut at an archaeological site Virje-Sušine in Northern Croatia dated in late Iron Age (La Tène C period, 2/
Tena Karavidović   +1 more
doaj  

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