Results 41 to 50 of about 73,960 (240)
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
Sampling Loop Test Check Evaluation of Secondary System based on VAE-WSVM Data Mining
Zhongguo dianliAnalyze the hidden dangers existing in the sampling circuit of the secondary system, and in view of the defects that the existing methods are difficult to obtain large amount of data, based on the historical measurement data, the variational autoencoder ...
Xiangguo YIN +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Non-planar one-loop Parke-Taylor factors in the CHY approach for quadratic propagators
Journal of High Energy Physics, 2018 In this work we have studied the Kleiss-Kuijf relations for the recently introduced Parke-Taylor factors at one-loop in the CHY approach, that reproduce quadratic Feynman propagators.
Naser Ahmadiniaz +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Boundaries of amplituhedra and NMHV symbol alphabets at two loops
Journal of High Energy Physics, 2018 In this sequel to [3] we classify the boundaries of amplituhedra relevant for determining the branch points of general two-loop amplitudes in planar N=4 $$ \mathcal{N}=4 $$ super-Yang-Mills theory.
I. Prlina +3 more
doaj +1 more source
One-loop algebras and fixed flow trajectories in adjoint multi-scalar gauge theory
Journal of High Energy Physics, 2023 We study the one loop renormalisation of 4d SU(N) Yang-Mills theory with M adjoint representation scalar multiplets related by O(M) symmetry. General M are of field theoretic interest, and the 4d one loop beta function of the gauge coupling g 2 vanishes ...
Nadia Flodgren, Bo Sundborg
doaj +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source