Results 71 to 80 of about 23,557 (297)

Liveness Checking as Safety Checking

open access: yes, 2002
Temporal logic is widely used for specifying hardware and software systems. Typically two types of properties are distinguished, safety and liveness properties.
Armin Biere   +5 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Versatile and declarative dynamic programming using pair algebras

open access: yes, 2005
Steffen P, Giegerich R. Versatile and declarative dynamic programming using pair algebras. BMC Bioinformatics. 2005;6(1): 224.Background: Dynamic programming is a widely used programming technique in bioinformatics. In sharp contrast to the simplicity of
Peter Steffen   +5 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

LLM-Generated Invariants for Bounded Model Checking Without Loop Unrolling [PDF]

open access: yes
We investigate a modification of the classical Bounded Model Checking (BMC) procedure that does not handle loops through unrolling but via modifications to the control flow graph (CFG).
Pirzada, Muhammad A. A.; id_orcid   +3 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Strong coupling expansion of 12 BPS Wilson loop in SYM theory and 2-loop Green-Schwarz string in AdS5 × S5

open access: yesNuclear Physics B
The exact localization result for the expectation value of the 12 BPS circular Wilson loop in N=4 SYM theory is given in the planar limit by the famous Bessel function expression: 〈W〉=2NλI1(λ).
M. Beccaria   +2 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Efficient loop-check for multimodal KD45n logic

open access: yesLietuvos matematikos rinkinys, 2021
We introduce sequent calculus for multi-modal logic KD45n which uses efficient loop-check. Efficiency of the used loop-check is obtained by using marked modal operator squarei which is used as an alternative to sequent with histories ([2,3]).We use inference rules with or branches to make all rules invertible or semi-invertible.
openaire   +2 more sources

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito   +14 more
wiley   +1 more source

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