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Advanced Healthcare Materials, Volume 15, Issue 11, 20 March 2026.This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney +3 more
wiley +1 more source
Clinical &Translational Immunology, Volume 15, Issue 3, 2026.In IgA nephropathy (IgAN), innate and adaptive immune cells display distinct spatial compartmentalisation, with macrophages predominating within glomeruli and CD4+ T cells constituting the major immune population in inflammatory foci. Glomeruli with distinct pathological morphologies exhibit morphology‐dependent immune infiltration patterns and ...
Xing Chen +8 more
wiley +1 more source
Tissue injury after lithium treatment in human and rat postnatal kidney involves glycogen synthase kinase 3β-positive epithelium [PDF]
, 2012 It was hypothesized that lithium causes accelerated and permanent injury to the postnatally developing kidney through entry into epithelial cells of the distal nephron and inhibition of glycogen synthase kinase-3β (GSK-3β).
Christensen, Sten +5 more
core +1 more source
Distribution of Henle's loops may enhance urine concentrating capability
Biophysical Journal, 1986 A simple mathematical model that was developed by Charles S. Peskin (unpublished manuscript) for a single nephron is introduced and then extended to reflect the decreasing loop of Henle population as a function of increasing medullary depth. In the model, if all the loops turn at the same depth, the concentrating capability is limited by a factor of e ...
openaire +2 more sources
Emerging key roles for P2X receptors in the kidney [PDF]
, 2013 P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides. Whilst there is a wealth of literature
Birch, R. E. +3 more
core +2 more sources
A combined clinical and biomarker approach to predict diuretic response in acute heart failure [PDF]
, 2015 Background: Poor diuretic response in acute heart failure is related to poor clinical outcome. The underlying mechanisms and pathophysiology behind diuretic resistance are incompletely understood.
Bloomfield, Daniel M. +16 more
core +4 more sources
Optical properties of acute kidney injury measured by quantitative phase imaging [PDF]
, 2018 The diagnosis of acute kidney disease (AKI) has been examined mainly by histology, immunohistochemistry and western blot. Though these approaches are widely accepted in the field, it has an inherent limitation due to the lack of high-throughput and ...
Bhaduri +36 more
core +1 more source
Nefrología (English Edition)Renal diseases associated with hypomagnesemia are a complex and diverse group of tubulopathies caused by mutations in genes encoding proteins that are expressed in the thick ascending limb of the loop of Henle and in the distal convoluted tubule. In this
Víctor M. Garcia-Nieto +6 more
doaj +1 more source
Long-Term Exposure of Lead Acetate on Rabbit Renal Tissue [PDF]
, 2016 Background: Lead has been widely used in different industries for ages. It is one of the heavy metals, highly poisonous even at low doses, and has biochemical, physiological and behavioral side effects on human and animals.
Bargahi, Afshar +3 more
core +3 more sources
Simulation of lithium transport along the thin segments of Henle's loop
Kidney International, 1993 Although the renal clearance of lithium is widely used as an index of sodium and water delivery to the end of the proximal tubule, micropuncture studies of superficial nephrons suggest that lithium may be reabsorbed additionally in the loop of Henle. In order to examine the possibility of lithium transport in the thin loop segments of deep nephrons, we
Taniguchi, Junichi +3 more
openaire +2 more sources