Results 181 to 190 of about 16,687 (224)

Indinavir Crystallization Around the Loop of Henle: Experimental Evidence

JAIDS Journal of Acquired Immune Deficiency Syndromes, 2001
To determine the probable site of the nephron and the plasma indinavir (IDV) concentration at which intrarenal IDV crystallization occurs.We performed in vitro crystallization experiments in IDV solutions simulating conditions found in the nephron.To determine intrarenal IDV concentrations at which conditions in the nephron allow crystallization ...
Dieleman, Jeanne, Salahuddin, S (Saima), Hsu, YS (Yeffrey), Burger, DM, Gyssens, ICJ (Inge), Sturkenboom, MCJM, Stricker, Bruno, Kok, Dik   +7 more
openaire   +3 more sources

Claudin Function in the Thick Ascending Limb of Henle's Loop

Annals of the New York Academy of Sciences, 2009
During the past decade, claudins have been established as major determinants of paracellular permeablilty in epithelia. In the kidney, each nephron segment expresses a distinct pattern of claudins. Cells of the thick ascending limb of Henle's loop (TAL), which is characterized by high paracellular cation permeability, co‐express an unusually large ...
Günzel, Dorothee, Haisch, Lea, Pfaffenbach, Sandra, Krug, Susanne M., Milatz, Susanne, Amasheh, Salah, Hunziker, Walter, Müller, Dominik   +7 more
openaire   +2 more sources

Function of Thin Segments of Henle’s Loop

1991
It is well known that the renal medulla plays an important role in the generation of concentrated urine, which is critical in the maintenance of body fluid osmolality. Since the proposal of the operation of countercurrent systems in the renal medulla by Kuhn and his associates [1–3], it has been widely accepted that the loop structures of the nephron ...
Masashi Imai, Koji Yoshitomi, Yoshiaki Kondo, Junichi Taniguchi, Chizuko Koseki, Taisuke Isozaki, Kaoru Tabei, Shigeru Koyama   +7 more
openaire   +1 more source

Transport Characteristics of the Loop of Henle

1978
The loop of Henle was early identified as a structure essential for the concentration of the urine, since it occurs only in birds and mammals, the two classes that produce urine with osmolality higher than the blood. Subsequent study of the loop of Henle has mainly involved its role in urinary concentrating mechanisms.
Maurice B. Burg, John L. Stephenson
openaire   +1 more source

The Physiology of the Loop of Henle

2009
This chapter reports the morphology and function of the thick ascending limb (TAL) of the loop of Henle a crucial segment for many tasks of the nephron. Indeed, the TAL is a mainstay not only for the direct reabsorption of sodium, potassium, and divalent cations but also for its indirect role in the urine renal water reabsorption, overall acid-base ...
Capasso G., Trepiccione F., Zacchia M.
openaire   +1 more source

Tubuloglomerular Feedback Signal Transduction in a Short Loop of Henle

Bulletin of Mathematical Biology, 2009
In previous studies, we used a mathematical model of the thick ascending limb (TAL) to investigate nonlinearities in the tubuloglomerular feedback (TGF) loop. That model does not represent other segments of the nephron, the water, and NaCl transport along which may impact fluid flow rate and NaCl transport along the TAL.
Layton, Anita T., Edwards, Aurélie
openaire   +2 more sources

Evidence of calcium phosphate supersaturation in the loop of Henle

American Journal of Physiology-Renal Physiology, 1996
We have used published rat micropuncture data to construct a matrix of ion concentrations along the rat nephron. With an iterative computer model of known ion interactions, we calculated relative supersaturation ratios in all nephron segments. The collecting ducts and urine showed expected supersaturation with stone-forming salts.
J R, Asplin, N S, Mandel, F L, Coe
openaire   +2 more sources

Bicarbonate transport along the loop of Henle effects of adrenal steroids

American Journal of Physiology-Renal Physiology, 1995
The role of adrenal steroids in the regulation of bicarbonate absorption in the loop of Henle was studied by in vivo microperfusion. Bicarbonate transport (JHCO3) was measured by microcalorimetry and fluid reabsorption by [14C]inulin, 7-10 days after surgery, in 1) sham-operated control rats, 2) adrenalectomized (Adx) rats, 3) Adx rats receiving ...
UNWIN R., CAPASSO, Giovambattista, GIEBISCH G., CAPASSO G.   +3 more
openaire   +3 more sources

Volume reabsorption by the Loop of Henle: A micropuncture study

Experientia, 1980
The observed extension of glomerulo-tubular beyond the proximal tube is thought to be due either to flow dependent reabsorption by non-accessible proximal segments and pars recta, or to osmotic volume flow out of the descending limb of the loop of Henle.
E, Bartoli, L E, Earley
openaire   +2 more sources

Effect of pH on Cl- transport in TAL of Henle's loop

American Journal of Physiology-Renal Physiology, 1987
To further characterize the mechanism of Cl- transport across the hamster thin ascending limb (TAL) of Henle's loop, we examined effects of pH on Cl- permeability as determined by either the choline chloride diffusion voltage or the lumen-to-bath 36Cl flux in the isolated segments perfused in vitro.
Y, Kondo, K, Yoshitomi, M, Imai
openaire   +2 more sources