Results 81 to 90 of about 41,623 (217)
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Modelling and Simulation in Engineering, 2016 Automation of the robust control system synthesis for uncertain systems is of great practical interest. In this paper, the loop shaping step for synthesizing quantitative feedback theory (QFT) based controller for a two-phase permanent magnet stepper ...
Nitish Katal, Shiv Narayan
doaj +1 more source
Automatic tuning of paper machines cross-direction controllers via linear matrix inequalities
Journal of Electrical Systems and Information Technology, 2015 The paper machine cross-direction (CD) process is a large-scale spatially distributed system. It is known to be severely ill-conditioned as the gain rolls down to zero for some of the process directions.
Mohammed E. Ammar, Guy A. Dumont
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Wideband Continuous-Time MASH ADCs: Principles, Challenges, and Prospects
IEEE Open Journal of the Solid-State Circuits SocietyContinuous-time (CT) delta-sigma modulator (DSM) is a popular choice for its inherent aliasing and resistive input impedance characteristics. With the increased demands for wide-bandwidth (BW) and high-dynamic range (DR), multistage noise shaping (MASH ...
Ke Li +4 more
doaj +1 more source
Nature Communications, 2019 Full spectral and temporal control of light has a multitude of applications but is often limited in frequency resolution. The authors implement a scheme using a frequency shifting optical loop for optical field spectral shaping with a high degree of ...
Côme Schnébelin +2 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source