Results 81 to 90 of about 38,623 (265)

The processes of organizational learning and innovation: a longitudinal case study (1986-1995) in a company of brazilian oil sector

Revista Produção Online, 2011
Innovation is one important factor for companies. This study presents a longitudinal case study focusing on the learning processes associated to innovation on an oil industry company. To conduct the study, which was of exploratory nature, interviews were
José Antônio Valle Antunes Júnior, Ivan de Pellegrin, Rodrigo Pinto Leis, Marco Zimmer, Guilherme Luís Roehe Vaccaro, Daniel Pacheco Lacerda   +5 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Practical approaches to group-level multi-objective Bayesian optimization in interaction technique design

Collective Intelligence
Designing interaction techniques for end-users often involves exploring vast design spaces while balancing many objectives. Bayesian optimization offers a principled human-in-the-loop method for selecting designs for evaluation to efficiently explore ...
Yi-Chi Liao, George B Mo, John J Dudley, Chun-Lien Cheng, Liwei Chan, Per Ola Kristensson, Antti Oulasvirta   +6 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Cohomology of loop spaces of the symmetric space $EI$ [PDF]

Homology, Homotopy and Applications, 2013
In the paper under review, the author determines the mod \(p\) cohomology of the loop space and the double loop space of the symmetric space of exceptional type \(EI\). The cohomology of \(EI\) was determined by \textit{K. Ishitoya} [Proc. Japan Acad., Ser. A 53, 56--60 (1977; Zbl 0395.57029)] and \textit{K. Ishitoya} and \textit{H. Toda} [J.
openaire   +3 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Decompositions of certain loop spaces

Journal of Pure and Applied Algebra, 2003
The author studies the decomposition of loop spaces of: (1) mapping cones of maps between wedge products of Moore spaces; and (2) spaces he calls \(\mathbb{Z}/p\)-conformal which were defined by \textit{J. A. Neisendorfer} and \textit{T. Miller} [Illinois J. Math. 22, 565-579 (1978; Zbl 0396.55011)].
openaire   +1 more source

Spaces of rational loops on a real projective space [PDF]

Transactions of the American Mathematical Society, 2001
AMS-LaTeX, 11 pages, 2 ...
openaire   +2 more sources

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source