Results 101 to 110 of about 6,563,661 (318)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Homology operations and cosimplicial iterated loop spaces
, 2014 If X is a cosimplical $E_{n+1}$ space then Tot(X) is an $E_{n+1}$ space and its mod 2 homology $H_*(Tot(X))$ has Dyer-Lashof and Browder operations. It's natural to ask if the spectral sequence converging to $H_*(Tot(X))$ admits compatible operations. In
Hackney, Philip
core +1 more source
Closing the loop or squaring the circle? Locating generative spaces for the circular economy
, 2016 Heightened concerns about long-term sustainability have of late enlivened debates around the circular economy (CE). Defined as a series of restorative and regenerative industrial systems, parallel socio-cultural transformations have arguably received ...
K. Hobson
semanticscholar +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Diagram spaces, diagram spectra, and spectra of units
, 2012 This article compares the infinite loop spaces associated to symmetric spectra, orthogonal spectra, and EKMM S-modules. Each of these categories of structured spectra has a corresponding category of structured spaces that receives the infinite loop space
Elmendorf +9 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Magnetic Monopole in the Loop Representation
, 2004 We quantize the electromagnetic field in the presence of a static magnetic monopole, within the loop-representation formalism. We find that the loop-dependent wave functional becomes multivalued, in the sense that it acquires a dependence on the surfaces
Alexander López +3 more
core +3 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Quasi-interpolation projectors for subdivision function spaces
Graphical ModelsSubdivision surfaces as an extension of splines have become a promising technique for addressing PDEs on models with complex topologies in isogeometric analysis.
Hailun Xu, Zepeng Wen, Hongmei Kang
doaj +1 more source
Моделирование и анализ информационных систем, 2020 Spatially inhomogeneous structures of light waves are used as a mechanism of compacting information in optical and fiber-optic communication systems.
Evgenii P. Kubyshkin +1 more
doaj +1 more source