Results 121 to 130 of about 6,563,661 (318)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Construction of 3D Indoor Topological Models Based on Improved Face Sorting

ISPRS International Journal of Geo-Information
Indoor location-based services and applications need to obtain information about the indoor spatial layouts and topological relationships of indoor spaces. The 3D city modeling data standard CityGML describes the indoor geometric and semantic information
Qun Sun, Xinwu Zhan, Pu Tang
doaj   +1 more source

The Combinatorics of Iterated Loop Spaces

, 2003
It is well known since Stasheff's work that 1-fold loop spaces can be described in terms of the existence of higher homotopies for associativity (coherence conditions) or equivalently as algebras of contractible non-symmetric operads.
Batanin, M. A.
core   +1 more source

Decompositions of certain loop spaces

Journal of Pure and Applied Algebra, 2003
The author studies the decomposition of loop spaces of: (1) mapping cones of maps between wedge products of Moore spaces; and (2) spaces he calls \(\mathbb{Z}/p\)-conformal which were defined by \textit{J. A. Neisendorfer} and \textit{T. Miller} [Illinois J. Math. 22, 565-579 (1978; Zbl 0396.55011)].
openaire   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

The processes of organizational learning and innovation: a longitudinal case study (1986-1995) in a company of brazilian oil sector

Revista Produção Online, 2011
Innovation is one important factor for companies. This study presents a longitudinal case study focusing on the learning processes associated to innovation on an oil industry company. To conduct the study, which was of exploratory nature, interviews were
José Antônio Valle Antunes Júnior, Ivan de Pellegrin, Rodrigo Pinto Leis, Marco Zimmer, Guilherme Luís Roehe Vaccaro, Daniel Pacheco Lacerda   +5 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Practical approaches to group-level multi-objective Bayesian optimization in interaction technique design

Collective Intelligence
Designing interaction techniques for end-users often involves exploring vast design spaces while balancing many objectives. Bayesian optimization offers a principled human-in-the-loop method for selecting designs for evaluation to efficiently explore ...
Yi-Chi Liao, George B Mo, John J Dudley, Chun-Lien Cheng, Liwei Chan, Per Ola Kristensson, Antti Oulasvirta   +6 more
doaj   +1 more source