Results 91 to 100 of about 672,301 (303)
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Sharia Issues on Loot Boxes in Online Games and Esport
SAMARAH: Jurnal Hukum Keluarga dan Hukum Islam, 2023 Online games and esports have attracted Muslims across Southeast Asia. However, this phenomenon has created some issues pertaining to sharia such as purchasing loot boxes while playing online games.
Amir Fazlim Jusoh @ Yusoff +1 more
semanticscholar +1 more source
Advanced Science, EarlyView.A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu +15 more
wiley +1 more source
The prevalence of loot boxes in mobile and desktop games [PDF]
, 2020 Background and Aims Loot boxes are items in video games that may be bought for real-world money but provide randomized rewards. Formal similarities between loot boxes and gambling have led to concerns that they may provide a ‘gateway’ to gambling amongst
Ballou, Nicholas +4 more
core +1 more source
Post‐Translational Modifications in Animal Circadian Clocks
Advanced Science, EarlyView.Circadian clocks coordinate physiology with daily environmental cycles through conserved transcriptional–translational feedback loops. This review summarizes how post‐translational modifications fine‐tune clock function, highlights the evolutionary convergence of circadian timekeeping in Drosophila and mammals, and emphasizes the central of these ...
Xianhui Liu, Yong Zhang
wiley +1 more source
Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution
Advanced Science, EarlyView.Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley +1 more source
A content analysis of in-game microtransaction advertisements [PDF]
, 2022 This research analyzed microtransaction advertisements in free-to-play PlayStation 4 video games for the presence of enticement methods found in gambling advertisements and motivation factors previously assigned to the purchase of loot boxes (Abarbanel
Meyer, Nigel
core +1 more source
Computational Microscopy of Spatial Dopant Distribution in Conjugated Polymer
Advanced Electronic Materials, EarlyView.The study employed molecular dynamics simulations to investigate the distribution of dopants in conjugated polymers. The simulations revealed that dopants are randomly distributed without forming clusters, contrasting with experimental findings of dopant clustering.
Joshua Wheeler, Igor Zozoulenko
wiley +1 more source
No effect of short term exposure to gambling like reward systems on post game risk taking
Scientific Reports, 2022 Is engaging with gambling-like video game rewards a risk factor for future gambling? Despite speculation, there are no direct experimental tests of this “gateway hypothesis”.
Nicholas J. D’Amico +6 more
doaj +1 more source
American Journal of Botany, EarlyView.Abstract Interpretations of evolutionary outcomes are limited without incorporation of physiological ecology, and ecophysiological interpretations would benefit from incorporating evolutionary perspectives. Although there has been a rise of studies in the last 20 years between these fields, evolutionary studies that incorporate plant physiology have ...
Haley A. Branch
wiley +1 more source