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<i>WDJ-S4</i>, a standardized herbal formula, promotes gastrointestinal motility via modulation of the acetylcholine pathway in a loperamide-induced functional dyspepsia mice. [PDF]

Pharm Biol
Hwang SJ, Seo CS, Baek DC, Woo TW, Wang JH, Lee JS, Choi YJ, Gu JY, Kim DS, Son CG.   +9 more
europepmc   +1 more source

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Chitosan oligosaccharides attenuate loperamide-induced constipation through regulation of gut microbiota in mice

Carbohydrate Polymers, 2021
Junping Zheng
exaly   +2 more sources

Gut indigenous Ruminococcus gnavus alleviates constipation and stress-related behaviors in mice with loperamide-induced constipation.

Food & Function, 2023
Refractory constipation is the most severe form of constipation, and its etiology remains unknown. The symptoms of constipation occur repeatedly, which brings great pain to the patient's body and psychology. Accumulating studies suggest that constipation
Rong Li, Sheng Xu, Bei Li, Bo Zhang, Wei-Hua Chen, Die Dai, Zhi Liu   +6 more
semanticscholar   +1 more source

Broccoli-Derived Exosome-like Nanoparticles Alleviate Loperamide-Induced Constipation, in Correlation with Regulation on Gut Microbiota and Tryptophan Metabolism.

Journal of Agricultural and Food Chemistry, 2023
Constipation, a common gastrointestinal dysfunction, damages patients' life quality and predisposes them to other serious diseases. Current strategies against constipation often cause drug dependency and side effects.
Tianchi Duan, Xiaoyuan Wang, Xinyue Dong, Chennan Wang, Lu Wang, Xingbin Yang, Ting Li   +6 more
semanticscholar   +1 more source

Lychee Pulp-Derived Dietary Fiber-Bound Phenolic Complex Upregulates the SCFAs-GPRs-ENS Pathway and Aquaporins in Loperamide-Induced Constipated Mice by Reshaping Gut Microbiome.

Journal of Agricultural and Food Chemistry, 2023
This study aimed to investigate the effects of the lychee pulp-derived dietary fiber-bound phenolic complex (DF-BPC) on a murine model of loperamide-induced constipation and its molecular mechanism associated with gut microbiota modification.
Lihong Dong, Zhuohui Xu, Guitao Huang, Ruifen Zhang, Mei Deng, F. Huang, Dongxiao Su   +6 more
semanticscholar   +1 more source

Identification of a novel adjuvant loperamide that enhances the antibacterial activity of colistin against MCR-1-positive pathogens in vitro/vivo.

Letters in Applied Microbiology, 2023
Severe infection with MDR Enterobacterales caused by the plasmid-induced colistin resistance gene MCR-1 is a serious public health challenge. In this case, it is necessary and pressing to find a treatment to overcome antibiotic resistance.
Yuqing Zhang, Liming Shi, Lu Lv, Yan Zhang, Huiping Chen   +4 more
semanticscholar   +1 more source

Lactobacillus rhamnosus Strains Relieve Loperamide-Induced Constipation via Different Pathways Independent of Short-Chain Fatty Acids

Frontiers in Cellular and Infection Microbiology, 2020
Increasing researches have confirmed the relationship between slow-transit constipation and gut microbiota dysbiosis. Many population and animal experiments have identified probiotics as effectors for the relief of constipation symptoms, but the specific
Gang Wang, Qiuxiang Zhang, Jianxin Zhao
exaly   +2 more sources

The protective effects of yellow tea extract against loperamide-induced constipation in mice

Food and Function, 2021
Yellow tea, a rare type tea from China, has a rich breadth of functional ingredients and benefits the gastrointestinal tract. However, it is not clear whether the yellow tea extract can alleviate constipation.
Pei-Qin Cao
exaly   +2 more sources

The effects of loperamide on excitatory and inhibitory neuromuscular function in the human colon

Neurogastroenterology and Motility, 2022
In most animal species, opioids alter colonic motility via the inhibition of excitatory enteric motor neurons. The mechanisms by which opioids alter human colonic motility are unclear.
Paul T. Heitmann, L. Keightley, L. Wiklendt, D. Wattchow, S. Brookes, N. J. Spencer, M. Costa, Philip G. Dinning   +7 more
semanticscholar   +1 more source