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Clinical Review: Loperamide Toxicity
Annals of Emergency Medicine, 2017Loperamide is a nonprescription opioid widely used for the treatment of diarrhea. Although it is relatively safe at therapeutic doses, increasing reports describe its misuse and abuse at very high doses either for euphoric effects or to attenuate symptoms of opioid withdrawal.
David N Juurlink
exaly +3 more sources
Critical Care Medicine, 2013
Introduction: Background: Loperamide is an opioid drug used as anti-diarrheal. Initially classified as schedule V drug, it is now available over the counter (OTC). Case Description: A 28 year old gentleman with past history of chron's disease, polysubstance abuse, depression and suicidal attempt ...
Arunima Rajbhandary +2 more
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Introduction: Background: Loperamide is an opioid drug used as anti-diarrheal. Initially classified as schedule V drug, it is now available over the counter (OTC). Case Description: A 28 year old gentleman with past history of chron's disease, polysubstance abuse, depression and suicidal attempt ...
Arunima Rajbhandary +2 more
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Clinical Pharmacology and Therapeutics, 1980
Effects of the currently marketed form of loperamide (Imodium capsules) that might relate to abuse potential were examined. Study I was a double-blind "dose run-up" in adult male subjects with a history of illicit drug use but no history of opioid addiction.
Jerome H Jaffe +2 more
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Effects of the currently marketed form of loperamide (Imodium capsules) that might relate to abuse potential were examined. Study I was a double-blind "dose run-up" in adult male subjects with a history of illicit drug use but no history of opioid addiction.
Jerome H Jaffe +2 more
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Radioimmunoassay of the antidiarrhoeal loperamide
Life Sciences, 1977Abstract Production of antibodies against loperamide was induced in rabbits that were repeatedly injected with a loperamide-protein conjugate. By using the antiserum, a sensitive and specific radioimmunoassay procedure for loperamide was developed. The drug could be assayed directly in human plasma in amounts as low as 50 picogram.
J. Heykants, M. Michiels, R. Hendriks
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Safety and efficacy of loperamide
The American Journal of Medicine, 1990Loperamide is a safe and effective antidiarrheal for the treatment of acute diarrhea. Efficacy data suggest that loperamide is more effective than the prescription drug diphenoxylate and an over-the-counter bismuth subsalicylate preparation. Loperamide is a safe drug, with few adverse reactions reported worldwide.
Philip C. Johnson, Charles D. Ericsson
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Antidiarrhetic loperamide hydrochloride
Acta Crystallographica Section C Crystal Structure Communications, 2012Single crystals of the anhydrous form of the title compound {systematic name: 1-[3-(dimethylcarbamoyl)-3,3-diphenylpropyl]-4-hydroxy-4-(4-chlorophenyl)piperidin-1-ium chloride}, C29H34ClN2O2+·Cl−, were obtained by diffusion of acetone into a solution in 2-propanol.
Jan W. Bats +4 more
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Metabolites of loperamide in rats
Biological Mass Spectrometry, 1979Following intraperitoneal administration to rats of [14C]loperamide, [carbonyl-14] 4-(p-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha, alpha-diphenyl-1-piperidine butyramide, metabolites in feces and urine were separated, and identified by means of mass spectrometry. In feces, six metabolites were identified in addition to the unchanged drug.
Satoshi Arakawa +4 more
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Influence of loperamide and loperamide oxide on the anal sphincter
Diseases of the Colon & Rectum, 1992The objective of this study was to investigate the effects of the opioid loperamide and its recently synthesized pharmacologically inactive prodrug loperamide oxide on the anal sphincter. In a double-blind, placebo-controlled crossover study, anorectal manometry was performed in 12 healthy volunteers five hours after oral bolus application of 10 mg of ...
M. Göke +3 more
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Effects of the prodrug loperamide oxide, loperamide, and placebo on jejunal motor activity
Digestive Diseases and Sciences, 1992This crossover, double-blind study investigated the effects of single oral doses of the prodrug loperamide oxide, which is reduced gradually to loperamide in the intestine, and loperamide on jejunal motor activity in 12 fasting healthy men. Five minutes after a phase III of the migrating motor complex (MMC), 2 mg loperamide oxide, 4 mg loperamide oxide,
G. Stacher +7 more
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Dose proportionality study of loperamide following oral administration of loperamide oxide
European Journal of Clinical Pharmacology, 1992The pharmacokinetics of loperamide, after oral administration of increasing doses (1 to 16 mg) of loperamide oxide, has been investigated in 10 healthy male volunteers, using a randomised cross-over design. Comparison of the maximum plasma loperamide concentration and AUC demonstrated that the bioavailability of loperamide was proportional to the dose ...
Michael D. Rawlins +5 more
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