Results 91 to 100 of about 25,193 (261)

The Effects of Daridorexant on Patients With Comorbid Insomnia Disorder and Untreated Mild Obstructive Sleep Apnoea: A Post Hoc Subgroup Analysis of a Phase 3, Randomised Clinical Trial

open access: yesJournal of Sleep Research, EarlyView.
ABSTRACT Daridorexant, a dual orexin receptor antagonist, is approved for the treatment of insomnia disorder in adults. Approximately 30%–35% of patients with insomnia disorder also have obstructive sleep apnoea (OSA) of any severity. It is unclear whether sleep medications provide safe and effective treatment for insomnia in these patients.
Christopher J. Lettieri   +8 more
wiley   +1 more source

Smartphone Application With Health Coaching Facilitates Multi‐Symptom Improvement in IBS Patients: A Pilot Feasibility Trial

open access: yesNeurogastroenterology &Motility, EarlyView.
Benefits of a smartphone application and health coaching in IBS patients. ABSTRACT Background Irritable bowel syndrome (IBS), a disorder of the gut‐brain interaction, is associated with significant symptom burden and impaired psychosocial functioning.
Max Eisele   +6 more
wiley   +1 more source

Changes in the cortical GABAergic inhibitory system with ageing and ageing‐related neurodegenerative diseases

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend With ageing and age‐related neurodegenerative diseases, the amount of GABA and GABAergic inhibition as well as the modulation (indicated by sine wave) of GABAergic inhibition is reduced, whereas excitation is increased. In many parts of the brain, this leads to a mismatch of facilitatory (green neurons) and inhibitory (red ...
Wolfgang Taube, Benedikt Lauber
wiley   +1 more source

BIOTRANSFORMATION AND EXCRETION OF LORAZEPAM IN PATIENTS WITH CHRONIC RENAL FAILURE [PDF]

open access: green, 1976
Roger K. Verbeeck   +3 more
openalex   +1 more source

Osmotic Demyelination Syndrome in a Patient With Schizophrenia: A Case Report

open access: yesNeuropsychopharmacology Reports, Volume 45, Issue 4, December 2025.
A man with schizophrenia developed osmotic demyelination syndrome after rapid correction of polydipsia‐induced hyponatremia, presenting with pseudobulbar palsy & severe EPS. MRI confirmed pontine and basal ganglia lesions. This report highlights ODS as key differential from antipsychotic side effects.
Yin‐Chen Lai, Chen‐Chia Lan
wiley   +1 more source

Menstrual psychosis with a marked response to carbamazepine

open access: yesPsychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.
Abstract Background Menstrual psychosis was first defined by Brockington in 1998 as a form of cycloid psychosis, the key features of which are an acute onset occurring against a background of normal mental functioning, brief duration, psychotic features, and a circadian periodicity that aligns with the menstrual cycle.
Atsuo Morisaki   +3 more
wiley   +1 more source

Evaluating Current Practice of Prescribing as Required Medications for Psychiatric Inpatients

open access: yesBJPsych Open
Aims Pro re nata (PRN) medications are commonly prescribed for psychiatric patients on admission, often at maximum daily dose (MaxD). We intended to evaluate prescribing patterns for PRN medications, their MaxD, and rationale, specifically in the first ...
Naveen Lalli   +4 more
doaj   +1 more source

Metoclopramide versus metoclopramide and lorazepam. Superiority of combined therapy in the control of cisplatin-induced emesis [PDF]

open access: bronze, 1989
Craig J. Gordon   +4 more
openalex   +1 more source

An International ASXL3 Natural History Study: Deep Phenotypic Analyses Including Detailed Reports of a Milder Phenotype, Novel Associations, and Clinical Recommendations

open access: yesAmerican Journal of Medical Genetics Part A, Volume 197, Issue 11, November 2025.
ABSTRACT Natural History Studies can help inform clinician and caregiver expectations, form the basis of management guidelines, and provide a comparator for therapeutic intervention. In rare conditions, where collection of prospective longitudinal data is untimely and impractical, quasi‐natural history data—from multiple individuals of different ages ...
E. Woods   +16 more
wiley   +1 more source

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